PMID: 8594945Dec 1, 1995Paper

Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats

The American Journal of Physiology
T WoltmanRoger D Reidelberger

Abstract

To assess the importance of triglyceride digestion products in producing satiety, we determined the effects of duodenal infusions of triolein, oleic acid, and oleic acid plus monoolein on meal patterns in ad libitum-feeding rats. Oleic acid and oleic acid plus monoolein inhibited feeding similarly; triolein's effect was delayed and fourfold less potent. We then used the type A cholecystokinin (CCK-A)-receptor antagonist devazepide to assess the importance of CCK in mediating the anorexia produced by oleic acid. Oleic acid (at 320, 440, and 640 mumol/h) inhibited 3-h intake dose dependently by 32, 56, and 75%, respectively. Devazepide (1 or 2 mg/kg) blocked the responses to the 320 mumol/h dose, but had little if any effect on responses to the larger doses. Devazepide (1 mg/kg) did block anorexic responses to 3-h cholecystokinin octapeptide infusions (3 and 10 nmol.kg-1.h-1 iv) that inhibited 3-h intake by 25 and 65%, respectively. Our results suggest that the satiety response to triolein is produced by the products of triolein digestion and that CCK plays a significant, indispensable role in mediating the satiety response to duodenal delivery of small but not large loads of oleic acid.

Citations

Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E CoxS T Meller
May 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Jul 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Aug 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miriam Goebel-StengelJoseph R Reeve
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A RandichS S Bharaj
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R D ReidelbergerJ Permert
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerDean Heimann
May 8, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerJohan Permert
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Apr 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Nov 13, 2004·Endocrinology·Prasanth K ChelikaniRoger D Reidelberger
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Nov 5, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Jan 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Roger ReidelbergerPrasanth K Chelikani

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