PMID: 9159209Feb 1, 1997Paper

Role of cholesterol in the regulation of renal phosphate transport

Frontiers in Bioscience : a Journal and Virtual Library
H WangM Levi

Abstract

The kidney plays a critical role in the regulation of inorganic phosphate (Pi) homeostasis through changes in the proximal tubular apical membrane Na-dependent Pi (Na/Pi) transport activity. In response to alterations in dietary Pi intake and during the aging process, changes in renal Na/Pi transport activity are inversely correlated with apical membrane cholesterol content. Cholesterol regulates Na/Pi transport activity by fluidity-dependent and fluidity-independent mechanisms, including regulation of Na/Pi protein transcription, synthesis, and trafficking to and from the plasma membrane.

Citations

Aug 19, 2005·American Journal of Physiology. Cell Physiology·Corina BalutDanny Jans
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer

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