Role of cholesterol metabolism in the anticancer pharmacology of selective estrogen receptor modulators.

Seminars in Cancer Biology
Diego Gómez-CoronadoMaría E Fernández-Suárez

Abstract

Selective estrogen receptor modulators (SERMs) are a class of compounds that bind to estrogen receptors (ERs) and possess estrogen agonist or antagonist actions in different tissues. As such, they are widely used drugs. For instance, tamoxifen, the most prescribed SERM, is used to treat ERα-positive breast cancer. Aside from their therapeutic targets, SERMs have the capacity to broadly affect cellular cholesterol metabolism and handling, mainly through ER-independent mechanisms. Cholesterol metabolism reprogramming is crucial to meet the needs of cancer cells, and different key processes involved in cholesterol homeostasis have been associated with cancer progression. Therefore, the effects of SERMs on cholesterol homeostasis may be relevant to carcinogenesis, either by contributing to the anticancer efficacy of these compounds or, conversely, by promoting resistance to treatment. Understanding these aspects of SERMs actions could help to design more efficacious therapies. Herein we review the effects of SERMs on cellular cholesterol metabolism and handling and discuss their potential in anticancer pharmacology.

References

May 9, 1977·Biochemical and Biophysical Research Communications·A M FogelmanG Popják
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H W ChenA A Kandutsch
Oct 1, 1992·Atherosclerosis·H GyllingT A Miettinen
Jan 1, 1992·Annual Review of Nutrition·S B Kritchevsky, D Kritchevsky
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M JakóbisiakZ Darzynkiewicz
Sep 1, 1991·European Journal of Biochemistry·L Sepp-LorenzinoP S Coleman
Apr 8, 1989·BMJ : British Medical Journal·C G IslesA F Lever
Sep 1, 1989·European Journal of Haematology·C P MullerB Steinke
Oct 1, 1988·British Journal of Cancer·P F BruningW J Nooyen
Feb 9, 1974·Lancet·G RoseJ Stamler
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Inbar, M Shinitzky
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Jan 1, 1984·Epidemiologic Reviews·A J McMichaelD G Zaridze
Mar 30, 1994·Biochemical and Biophysical Research Communications·D Pérez-Sala, F Mollinedo
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H GyllingT A Miettinen
Mar 6, 1996·Journal of the National Cancer Institute·E P Gelmann
Jun 7, 1996·The Journal of Biological Chemistry·U GundimedaR Gopalakrishna
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·Y HozumiM Miyata
Jun 19, 1998·Biochimica Et Biophysica Acta·A Babiker, U Diczfalusy
Dec 29, 1998·Metabolism: Clinical and Experimental·A L HolleranJ K Kelleher
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·N AltanS M Simon
Jul 27, 1999·Metabolism: Clinical and Experimental·J Martínez-BotasM A Lasunción
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Martínez-BotasM A Lasuncion
Dec 9, 2000·Biochimica Et Biophysica Acta·D W Russell
Jun 28, 2001·Leukemia & Lymphoma·J DimitroulakosL Z Penn
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R I Kelley, G E Herman
Mar 16, 2002·European Journal of Biochemistry·Yajaira SuárezMiguel A Lasunción
May 4, 2002·Molecular and Cellular Endocrinology·Anne Grete ByskovLise Leonardsen
Jul 23, 2002·The Biochemical Journal·W David NesStephen T Furlong
Jan 30, 2003·Clinical Biochemistry·K KolanjiappanS Manoharan
Feb 14, 2003·The New England Journal of Medicine·B Lawrence Riggs, Lynn C Hartmann

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Citations

May 20, 2021·Biochemical Pharmacology·Babita MadanDavid J Leaver
May 31, 2021·Biochemical Pharmacology·Miguel A LasunciónDiego Gómez-Coronado
May 21, 2021·Seminars in Cancer Biology·Marta Farràs, Joan Carles Escolà-Gil
Jul 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·María E Fernández-SuárezDiego Gómez-Coronado

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