Role of cholinergic and adrenergic pathways of the medial septal area in the control of water intake and renal excretion in rats

Pharmacology, Biochemistry, and Behavior
D F LeiteJ V Menani

Abstract

In this study, we investigated an interaction between noradrenergic and cholinergic pathways of the medial septal area (MSA) on the control of water intake and urinary electrolyte excretion by means of injection of their respective agonists. Noradrenaline (a nonspecific alpha-adrenergic agonist) and clonidine (an alpha 2-adrenergic agonist), but not phenylephrine (an alpha 1-adrenergic agonist), induced natriuresis and kaliuresis. alpha-Adrenergic activation had no effect on the natriuresis and kaliuresis induced by carbachol (a cholinergic agonist) and it inhibited the antinatriuresis and antikaliuresis induced by isoproterenol (a beta-adrenergic agonist). Interactions related to volume excretion are complex, alpha-Adrenergic activation induced a mild diuresis and inhibited the antidiuresis induced by isoproterenol, but phenylephrine combined with carbachol induced antidiuresis. The water intake induced by carbachol was inhibited by clonidine and noradrenaline, but not phenylephrine. These results show an asymmetry in the interaction between alpha-adrenergic and cholinergic receptors concerning water intake and electrolyte excretion.

References

Jun 1, 1976·Canadian Journal of Physiology and Pharmacology·L A CamargoM R Covian
Aug 1, 1979·Pharmacology, Biochemistry, and Behavior·L A CamargoM R Covian
Aug 15, 1977·European Journal of Pharmacology·J M Cedarbaum, G K Aghajanian
Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·W A SaadM R Covian
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S BaldisseraJ Antunes-Rodrigues
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·S F Leibowitz
Oct 15, 1981·European Journal of Pharmacology·P SchmidtJ Nagy
Apr 30, 1984·Brain Research·M J FreglyJ E Greenleaf
Apr 1, 1984·Brain Research Bulletin·M J FreglyJ E Greenleaf
Feb 1, 1984·Pharmacology, Biochemistry, and Behavior·J V MenaniW A Saad

❮ Previous
Next ❯

Citations

Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·X YangJ R Pauly
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M M YadaL A de Luca Júnior
Jul 6, 2004·Autonomic Neuroscience : Basic & Clinical·Wilson Abrão SaadIsmael Francisco Mota Siqueira Guarda
Aug 20, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A SaadWillian A Saad
Sep 10, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A A CamargoW Abrão Saad
May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·D D Schwartz, T P Clark
Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·D D SchwartzT P Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.