PMID: 19930906Nov 26, 2009Paper

Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
Da-wei WangYong-ming Yao

Abstract

The cholinergic anti-inflammatory pathway (CAP) is a neurophysiological mechanism that regulates the immune system. The CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system, including the lungs, spleen, liver, kidneys and gastrointestinal tract. Acetylcholine can interact with alpha7 nicotinic acetylcholine receptors (alpha7 nAchR) expressed by macrophages and other cytokine producing cells, down-regulate pro-inflammatory cytokine synthesis and prevent tissue damage. Herein is a review of the neurophysiological mechanism in which the CAP regulates inflammatory response, as well as its potential interventional strategy for inflammatory diseases.

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