Role of cholinergic receptors in memory retrieval depends on gender and age of memory

Behavioural Brain Research
Habiba RashidTouqeer Ahmed

Abstract

The phenomenon of utilizing information acquired in the past to make decision and performance in present depends on memory retrieval, which is affected in retrograde amnesia. Role of cholinergic receptors in memory retrieval is not much explored. In this study we evaluated the gender specific role of cholinergic receptors, i.e. muscarinic and nicotinic receptors, in memory retrieval in young Balb/c mice. Acute (only one injection, 30min before test) and sub-chronic (five days) muscarinic blockade (using scopolamine=1mg/kg) before test impaired retrieval of contextual fear memory in male (31.45±5.39% and 33.36±3.78% respectively) and female mice (22.88±5.73%; P<0.05), except sub-chronically treated female group (33.31±4.90%; P>0.05). Only sub-chronic nicotinic receptor antagonism (using methyllycaconitine MLA=87.5μg/kg and dihydro β erythroidine DHβE=1mg/kg) in female showed significantly higher freezing response than control during contextual fear memory retrieval (60.85±7.71% and 40.91±7.53% respectively; P<0.001). Acute and sub-chronic muscarinic antagonism (but not nicotinic antagonism) impaired spatial memory retrieval in male (P<0.05) but not in female mice (P>0.05). There was no effect of acute and sub-chronic cholinergic...Continue Reading

Citations

Apr 20, 2019·Pharmacological Reports : PR·Habiba Rashid, Touqeer Ahmed
Aug 10, 2019·Environmental Science and Pollution Research International·Sheta BiswasZahangir Alam Saud
Nov 12, 2020·Biological Trace Element Research·Muhammad Faisal IkramTouqeer Ahmed
May 28, 2019·Neuroscience and Biobehavioral Reviews·E R VelascoR Andero
Apr 9, 2021·Biological Trace Element Research·Hasan Ul BannaZahangir Alam Saud

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