PMID: 5257138Jun 1, 1969Paper

Role of chromatin in estrogen action in the uterus. II. Hormone-induced synthesis of nonhistone acidic proteins which restore histone-inhibited DNA-dependent RNA synthesis

Proceedings of the National Academy of Sciences of the United States of America
C S Teng, T H Hamilton

Abstract

Nonhistone acidic proteins were isolated, by equilibrium density centrifugation in 4 M cesium chloride, from the chromatin isolated and purified from the uterus of the ovariectomized rat or from calf endometrium. Evidence is presented to show (1) that arginine-rich histones are more effective inhibitors of chromatin-directed RNA synthesis in vitor than lysine-rich histones, (2) that the nonhistone acidic proteins of chromatin do not inhibit the synthesis of RNA directed by chromatin in vitro, (3) that added nonhistone acidic chromatin proteins effect a restoration of histone-inhibited RNA synthesis directed by chromatin in vitro, and (4) that the synthesis of nonhistone acidic chromatin proteins is under estrogen control in the uterus, but not in the liver. It is concluded that a major feature of the early action of estrogen in the uterus of the ovariectomized rat is the stimulation of synthesis and the accumulation in the interphase chromosomes of nonhistone acidic proteins which counter the inhibitory effect of histone on transcription by RNA polymerase. Presumably this would permit more and perhaps a new synthesis of RNA programmed for transport to the cytoplasm.

References

Sep 9, 1967·Nature·J A Butler, A R Chipperfield
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·W Benjamin, A Gellhorn
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·C S Teng, T H Hamilton
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Citations

Aug 1, 1976·Biochemical Genetics·M L CoomesD L Busbee
Sep 1, 1974·Bulletin of Experimental Biology and Medicine·A I MaiskiiP V Sergeev
May 1, 1977·Experimental Eye Research·R C BriggsH Rothstein
Mar 1, 1990·Journal of Steroid Biochemistry·K M Brantley, S M Whelly
Jan 1, 1979·Pharmacology & Therapeutics·S J Segal, S S Koide
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·G RoveraR Baserga
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A E MirskyN C Panda
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J S Bhorjee, T Pederson
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B Silverman, A E Mirsky
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T Pederson
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E Cohen, T H Hamilton
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W ScherC Friend
Oct 1, 1972·The Journal of Cell Biology·J E Froehlich, M Rachmeler
Dec 1, 1973·The Journal of Cell Biology·H M MaulG G Maul
Feb 4, 1979·Biochimica Et Biophysica Acta·P S Rudland, L Jimenez de Asua
Mar 14, 1972·Biochimica Et Biophysica Acta·N C Kostraba, T Y Wang
Dec 14, 1970·Biochimica Et Biophysica Acta·R J Kraemer, D S Coffey
Jan 1, 1975·Biochimie·L S DesaiG E Foley
Jun 1, 1972·Experimental Cell Research·J Dijkstra, S S Weide
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Nov 9, 1970·Biochemical and Biophysical Research Communications·G Stein, R Baserga
Mar 15, 1973·Experimental Cell Research·K M AndersonR M Couch
Nov 1, 1971·Experimental Cell Research·T Y Wang
Nov 1, 1972·Experimental Cell Research·K Fukuyama, W L Epstein
Mar 15, 1978·Experimental Cell Research·H G StunnenbergC E Sekeris
Apr 25, 1973·Journal of Molecular Biology·R L Seale, A I Aronson

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