PMID: 9435639Jan 22, 1998Paper

Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS

The American Journal of Physiology
M J LenczowskiF J Tilders

Abstract

Peripheral administration of lipopolysaccharide (LPS) may activate the hypothalamus-pituitary-adrenal (HPA) axis by way of both neural and humoral mechanisms. We have investigated whether biologically active endotoxin appears in the general circulation after intraperitoneal administration of LPS (5 or 100 micrograms/kg) to rats and whether this is a prerequisite for activation of this HPA axis. Within 15 min, endotoxin appeared in the general circulation, whereas elevations of plasma adrenocorticotropic hormone (ACTH), corticosterone, and interleukin (IL)-6 concentrations were not detected until 90 min after LPS injection. At this time, a marked interindividual variation was observed in plasma concentrations of endotoxin, ACTH, corticosterone, and IL-6. Elevated levels of plasma endotoxin were associated with elevated levels of ACTH, corticosterone, and IL-6. Intravenous administration of the LPS antagonist cationic antimicrobial protein 18 (5 mg/kg), which did not affect cytokine production in the peritoneal cavity, markedly reduced plasma ACTH, corticosterone, and IL-6 levels after 5 micrograms/kg LPS. Our results suggest that circulating endotoxin is required for the activation of the HPA axis. They also favor a role for cir...Continue Reading

References

Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer
Nov 1, 1991·Trends in Pharmacological Sciences·N J Rothwell
Jan 1, 1991·Physiological Reviews·M J Kluger
Jan 1, 1988·Reviews of Infectious Diseases·C A DinarelloS M Wolff
Dec 1, 1989·Brain Research Bulletin·W A BanksD A Durham
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H MatsumuraO Hayaishi
Sep 30, 1988·Biochemical and Biophysical Research Communications·Y NaitohH Imura
Oct 1, 1988·European Journal of Immunology·M HelleL A Aarden
Apr 1, 1986·American Journal of Surgery·P OlofssonP Olsson
Jun 30, 1994·The New England Journal of Medicine·C B Saper, C D Breder
Sep 26, 1994·Neuroscience Letters·W A BanksE G Gutierrez
Aug 15, 1994·Brain Research·L R WatkinsS F Maier
Mar 14, 1994·Brain Research·L R WatkinsS F Maier
Feb 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M Van DamF Berkenbosch
Mar 1, 1996·Journal of Endocrinological Investigation·M J van der MeerA R Hermus
Dec 1, 1995·Brain, Behavior, and Immunity·A V Turnbull, C Rivier
Feb 1, 1986·Immunology Today·J J OppenheimS K Durum

❮ Previous
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Citations

Nov 8, 2003·American Journal of Respiratory and Critical Care Medicine·Paul ForsytheHarissios Vliagoftis
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph RummelJoachim Roth
Apr 16, 2002·Infection and Immunity·S LiC M Blatteis
Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M NickersonM Fleshner
Apr 25, 2018·International Journal of Molecular Sciences·Junko MasudaMasaharu Seno
Sep 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z R ZimomraJ D Johnson
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Waldemar KanczkowskiStefan R Bornstein
Dec 17, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Aymam C de FigueiredoFernando R Gomes
Sep 29, 2020·Scientific Reports·Anna M KosyrevaLiliya P Mikhailova
Oct 16, 1999·Journal of Neuroendocrinology·N ShanksS L Lightman

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