Role of circulating miR-182 and miR-150 as biomarkers for cirrhosis and hepatocellular carcinoma post HCV infection in Egyptian patients

Virus Research
Noha Mohamed Hosni ShaheenRania H Khalifa

Abstract

In Egypt, liver diseases are exceptionally high, maintaining the highest prevalence of hepatitis C virus (HCV) worldwide, and increasing rates of hepatocellular carcinoma (HCC). Available diagnostic methods show poor performance in early diagnosis of HCC. Definite pathogenic factors contributing in the development of HCV are still lacking. MicroRNAs have been reported as promising biomarkers for cancers diagnosis and in virus-host interaction. This study was conducted to detect the role of miR-182 and miR-150 as biomarkers for development of cirrhosis and malignant transformation in HCV infected patients. The expression of miR-182 and miR-150 was evaluated using real-time quantitative PCR (qRT-PCR) in 120 subjects: 40 HCC patients, 40 hepatitis C patients (20 cirrhotic and 20 non-cirrhotic HCV genotype 4) and 40 healthy controls. In HCC, statistically significant decrease of miR-182 and miR-150 compared to non-cirrhotic HCV patients (p = 0.015, p = 0.006 respectively) and of miR-150 compared to controls (p = 0.039). In cirrhotic HCV patients, significant down regulation of miR-182 and miR-150 compared to non-cirrhotic HCV (p = 0.003, p = 0.024 respectively). On the other hand, significant upregulation of miR-182 was observed in...Continue Reading

Citations

Mar 29, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto ChumaNaoya Sakamoto
Nov 2, 2018·Viruses·Marie-Laure PlissonnierMirjam B Zeisel
Dec 25, 2019·BioMed Research International·Yao JiangHualin Tao
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
May 1, 2021·Cancers·José D Debes On Behalf Of The Escalon Consortium
Nov 17, 2021·Biomarkers in Medicine·Zhuo HanJianying Zhang

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