Role of citron kinase in dendritic morphogenesis of cortical neurons

Brain Research Bulletin
Ferdinando Di CuntoLorenzo Silengo

Abstract

Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have found that, in addition, it could play an important role in modulating the extension of neuronal processes. Using constitutively active and dominant negative mutants, we showed that citron kinase is involved in the morphologic differentiation of N1E-115 neuroblastoma cells induced by serum starvation. More importantly, quantitative analysis of citron kinase knockout cerebral cortex displayed that this molecule may differentially regulate the morphology of the dendritic compartment in corticocollicular versus callosally-projecting pyramidal neurons.

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Citations

Jun 5, 2003·Brain Research Bulletin·Diego Garbossa, Alessandro Vercelli
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Maddalena GrossiG Paolo Dotto
Aug 19, 2011·Molecular Biology of the Cell·Marta GaiFerdinando Di Cunto
Jul 3, 2004·Neuroreport·Brigitte M JockuschGünter Schwarz
Jan 17, 2009·The Journal of Comparative Neurology·Patrizia MuzziAlessandro Vercelli
Dec 1, 2017·Small GTPases·Federico T BianchiFerdinando Di Cunto

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