PMID: 11342807May 9, 2001Paper

Role of ClC-5 in the pathogenesis of hypercalciuria: recent insights from transgenic mouse models

Current Opinion in Nephrology and Hypertension
A S Yu

Abstract

Dent's disease is an inherited disorder characterized by hypercalciuria, low molecular weight proteinuria, and Fanconi syndrome, which is caused by inactivating mutations in ClC-5, a chloride channel expressed in endosomes of the proximal renal tubule. The role of ClC-5 in the pathogenesis of the hypercalciuria and other myriad manifestations of this disease, however, is largely unknown. New insights from three new transgenic mouse models of Dent's disease, reported in the past year, are discussed.

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Citations

Jun 30, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael LudwigArend Bökenkamp
Aug 21, 2002·Current Opinion in Nephrology and Hypertension·Vladimir MarshanskyDennis Brown
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May 15, 2003·The Journal of Biological Chemistry·Raha Mohammad-PanahChristine E Bear
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Kevin K Frick, David A Bushinsky

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