Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise

Journal of Applied Physiology
K J SmithP N Ainslie

Abstract

Cerebral blood flow (CBF) is temporally related to exercise-induced changes in partial pressure of end-tidal carbon dioxide (PetCO2 ); hyperoxia is known to enhance this relationship. We examined the hypothesis that preventing PetCO2 from rising (isocapnia) during submaximal exercise with and without hyperoxia [end-tidal Po2(PetO2 ) = 300 mmHg] would attenuate the increases in CBF. Additionally, we aimed to identify the magnitude that breathing, per se, influences the CBF response to normoxic and hyperoxic exercise. In 14 participants, CBF (intra- and extracranial) measurements were measured during exercise [20, 40, 60, and 80% of maximum workload (Wmax)] and during rest while ventilation (V̇e) was volitionally increased to mimic volumes achieved during exercise (isocapnic hyperpnea). While V̇ewas uncontrolled during poikilocapnic exercise, during isocapnic exercise and isocapnic hyperpnea, V̇ewas increased to prevent PetCO2 from rising above resting values (∼40 mmHg). Although PetCO2 differed by 2 ± 3 mmHg during normoxic poikilocapnic and isocapnic exercise, except for a greater poikilocapnic compared with isocapnic increase in blood velocity in the posterior cerebral artery at 60% Wmax, the between condition increases in int...Continue Reading

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Citations

Aug 9, 2017·Experimental Physiology·Kurt J Smith, Philip N Ainslie
May 17, 2018·European Journal of Applied Physiology·Michael M TymkoKurt J Smith
Apr 9, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Lindsay A EllisAli M McManus
Mar 1, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julien Vincent BrugniauxPhilip N Ainslie
Jun 8, 2018·Journal of Applied Physiology·Daniela Nowak-FlückJames P Fisher
Jan 17, 2019·High Altitude Medicine & Biology·Mathew G RiegerAli M McManus
Dec 24, 2018·Experimental Physiology·Rachel M StoneMichael M Tymko
Jan 24, 2019·Sports Medicine·Steven J Trangmar, José González-Alonso
Jan 9, 2020·The Journal of Physiology·Hannah G CaldwellPhilip N Ainslie
Oct 15, 2019·Medicine and Science in Sports and Exercise·Takaaki KomiyamaSoichi Ando
Jan 30, 2019·Medicine and Science in Sports and Exercise·Kurt J SmithDaniel J Green
Dec 7, 2018·Frontiers in Physiology·Jessica J SteventonPhil N Ainslie
Jan 16, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer S WilliamsMaureen J MacDonald
May 2, 2021·Experimental Physiology·Jay M J R CarrPhilip N Ainslie
Nov 4, 2021·Experimental Physiology·Jay M J R CarrRyan L Hoiland

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