Role of complement anaphylatoxin C3a in photodynamic therapy-elicited engagement of host neutrophils and other immune cells

Photochemistry and Photobiology
Ivana CecicM Korbelik

Abstract

Tumor treatment by photodynamic therapy (PDT) provokes a host-protective inflammatory and acute-phase response and an immune reaction. Neutrophilia manifested in this context is driven by multiple mediators of neutrophil chemotaxis orchestrated by an activated complement system. Mouse FsaR fibrosarcoma was used in this study to further investigate neutrophilia induced by Photofrin-based PDT. The complement anaphylatoxin C3a was identified as a major chemoattractant in the advanced phase of PDT-induced neutrophilia, because injecting mice with antibodies blocking its receptor C3aR significantly inhibited the increase in neutrophil levels 8 h after PDT. At the same time point, an increased C3aR expression was detected in neutrophils, monocytes and B lymphocytes in the blood of host mice. Peritoneal macrophages and mast cells harvested from treatment-naive mice exhibited elevated C3aR expression after coincubation in vitro for 8 h with PDT-treated FsaR cells. Thus, C3a emerges as one of the key effector molecules engaged in PDT-induced host response.

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Citations

Sep 2, 2006·Cancer Immunology, Immunotherapy : CII·Brandon Stott, Mladen Korbelik
Mar 26, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Pawel Mroz, Michael R Hamblin
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Sep 21, 2007·Photochemistry and Photobiology·Ivana CecicMladen Korbelik
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Aug 22, 2008·Journal of Photochemistry and Photobiology. B, Biology·Mladen Korbelik, Ivana Cecic
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Jan 30, 2020·Journal of Medical Case Reports·Elisabetta SorbelliniFabio Rinaldi

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Methods Mentioned

BETA
flow cytometry

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