PMID: 3745942Feb 1, 1986Paper

Role of complement in chlorpromazine-induced phototoxicity

The Journal of Investigative Dermatology
W Torinuki, H Tagami

Abstract

To evaluate the role of the complement system in inflammation induced by chlorpromazine (CPZ) and ultraviolet-A (UVA) irradiation, the phototoxic response in guinea pigs decomplemented by cobra venom factor was compared with that in saline-treated animals. Phototoxic lesions were induced in animals by intradermal injections of CPZ solution, followed by UVA irradiation. Clinically, the normal animals developed erythema and induration which showed a maximal response at 10 h with a mean value of 1.6 on a scale of 0 to 3+. The complement-depleted animals showed a weaker clinical response than the normal animals 6-24 h postirradiation (p less than 0.05). These clinical changes were associated with increased vascular permeability, as demonstrated by extravasation of i.v. injected Evans blue in saline-treated animals. In vitro UVA irradiation of serum containing CPZ resulted in a dose-dependent diminution of total complement activity. Such irradiated serum showed immunoelectrophoretic C3 conversion. These results suggest that the complement system is involved in the development of CPZ-induced phototoxic lesions.

Citations

Dec 22, 1999·Seminars in Cutaneous Medicine and Surgery·J H Epstein
Aug 11, 2007·Expert Opinion on Drug Safety·Kevin R Stein, Noah S Scheinfeld
Jan 1, 1992·Archives of Dermatological Research·H Tagami
Aug 1, 1995·Photodermatology, Photoimmunology & Photomedicine·T H KimJ I Youn
Apr 1, 1994·European Journal of Clinical Investigation·B P Morgan
Jun 1, 1987·Photochemistry and Photobiology·I E Kochevar

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