Role of complement system in patients with biopsy-proven immunoglobulin G4-related kidney disease

Human Pathology
Rong WangZhihong Liu

Abstract

Hypocomplementemia has been frequently reported in immunoglobulin G4-related kidney disease (IgG4-RKD). However, studies on the role of complement system in IgG4-RKD are lacking. A total of 40 429 renal biopsies from January 2010 to January 2018 were reexamined in the present study, and 17 patients were confirmed to meet the criteria of IgG4-RKD. According to the serum C3 levels, they were divided into 2 groups: the low-C3 group (C3 <0.8 g/L, n = 7) and the normal-C3 group (C3 ≥0.8 g/L, n = 10). Compared with the normal-C3-level group, the patients in the low-C3-level group had lower serum C4 concentrations (P = .025), higher serum IgG4 concentrations (P = .003), higher positive rates in rheumatoid factor (P = .033), more severe storiform fibrosis (P = .007) at diagnosis, and higher blood urea nitrogen levels at the latest test (P = .04). The serum levels of C3 were in negative correlation with the serum levels of IgG4 (P = .003), the levels of rheumatoid factor (P = .002), renal deposition of C1q (P = .028), storiform fibrosis (P < .001), scores of interstitial fibrosis (P = .015), the amount of renal IgG4-positive (IgG4+) plasma cells (P = .020), the ratios of IgG4+ plasma cells/CD138+ cells (P = .018), and the blood urea nit...Continue Reading

Citations

Aug 25, 2020·Journal of Investigative Medicine High Impact Case Reports·Pradnya Brijmohan BhattadEric Peterson
Jan 12, 2021·Journal of Immunology Research·Zhaocheng DongBaoli Liu
Apr 3, 2020·La Presse médicale·Benjamin De Sainte MarieNicolas Schleinitz
Aug 4, 2021·Indian Journal of Pathology & Microbiology·Kavita JainManimoy Bandopadhyay
Jun 14, 2019·Case Reports in Nephrology and Dialysis·Emmett Tsz Yeung WongChristopher Cheang Han Leo

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