Role of connexin43 in central nervous system injury

Experimental Neurology
Shenton S L ChewHelen V Danesh-Meyer

Abstract

Gap junctions are specialized cell-to-cell contacts that provide direct intercellular communication. In the central nervous system (CNS), gap junction coupling occurs between both neurons and glial cells. One of the most abundant gap junction proteins in the CNS is connexin43 (Cx43). The functional syncytium formed by astrocytes via Cx43 gap junction intercellular communication has, for example, been implicated in maintaining the homeostasis of the extracellular milieu of neurons. In particular, astrocytes are involved in the spatial buffering of many ions, signalling molecules and energy sources. In this review, the role of Cx43 following CNS injury is examined by combining evidence surrounding the response of Cx43 to CNS injury and the effects of Cx43 gap junction blockade on neuronal survival in various models of injury. Combined evidence suggests that transient blockade targeting the window of initial Cx43 upregulation observed following injury is potentially therapeutic.

References

Jul 1, 1992·The Journal of Cell Biology·A C CharlesM J Sanderson
May 13, 1991·Neuroscience Letters·C C NausJ X Wilson
Sep 1, 1990·British Journal of Pharmacology·E Puil, H el-Beheiry
Dec 1, 1995·Journal of Neurobiology·M NedergaardS A Goldman
Feb 9, 1996·Cell·N M Kumar, N B Gilula
Jun 1, 1996·Molecular and Cellular Neurosciences·K J ChandrossR Dermietzel
Dec 29, 1998·The Journal of Biological Chemistry·S A JohnJ N Weiss
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·G R JohnC F Brosnan
Apr 7, 2000·Brain Research. Brain Research Reviews·J I Nagy, J E Rash
Aug 11, 2001·Biochemical Society Transactions·W H Evans, S Boitano
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jorge E ContrerasJuan C Sáez
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marina V FrantsevaJose L Perez Velazquez
Apr 30, 2002·Brain Research. Molecular Brain Research·S-H LinL-C Yang
May 16, 2002·Journal of Cellular Physiology·Antonio De MaioJorge E Contreras
Jun 18, 2002·Cell Communication & Adhesion·C C NausT Nakase
Feb 13, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jose L Perez VelazquezChristian C Naus
May 14, 2003·Neurochemistry International·Gerald A Dienel, Nancy F Cruz
Jul 5, 2003·Stroke; a Journal of Cerebral Circulation·Taizen NakaseChristian C G Naus
Oct 31, 2003·Trends in Neurosciences·Michael V L BennettJuan C Sáez
Dec 19, 2003·Cell Communication & Adhesion·Taizen NakaseChristian C G Naus
Mar 11, 2004·The European Journal of Neuroscience·F BlomstrandC Giaume
Apr 20, 2004·Cardiovascular Research·Ben N G Giepmans
May 27, 2004·The American Journal of Pathology·Taizen NakaseChristian C G Naus
Sep 15, 2004·Current Opinion in Cell Biology·Charles StoutDavid L Paul
Dec 2, 2004·Brain Research. Brain Research Reviews·Jorge E ContrerasJuan C Sáez
Mar 2, 2005·Nature Reviews. Neuroscience·Goran SöhlKlaus Willecke
Aug 12, 2005·Journal of Neurochemistry·Christina NodinFredrik Blomstrand
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Mara H de Pina-BenabouRenato Rozental

❮ Previous
Next ❯

Citations

Aug 14, 2012·The Journal of Membrane Biology·W Howard EvansLuc Leybaert
Oct 28, 2011·Nature Neuroscience·Ethan A WinklerBerislav V Zlokovic
Jul 4, 2012·Brain : a Journal of Neurology·Joan Y W LiuSanjay M Sisodiya
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Osamu TakasuRichard S Hotchkiss
May 6, 2014·Experimental Neurology·Erica SarchielliGabriella B Vannelli
Jul 14, 2012·Stem Cells International·Anna JezierskiMahmud Bani-Yaghoub
Mar 13, 2014·FEBS Letters·Christina L GrekGautam S Ghatnekar
Mar 15, 2016·Frontiers in Integrative Neuroscience·Venkata S S S SajjaPamela J VandeVord
Apr 14, 2016·Journal of Molecular Neuroscience : MN·Edilene Siqueira SoaresMaria Alice da Cruz-Höfling
Aug 5, 2015·Drug Delivery and Translational Research·Ying-Shan ChenIlva D Rupenthal
Nov 13, 2012·Developmental Biology·Stephanie J MungerAlexander M Simon
Jun 30, 2015·Cellular and Molecular Life Sciences : CMLS·Elke DecrockLuc Leybaert
Oct 27, 2012·International Journal of Pharmaceutics·Keng-Chih LiuIlva D Rupenthal
Nov 5, 2013·The Spine Journal : Official Journal of the North American Spine Society·Xuehua LiuQingjun Su
Feb 5, 2013·The Journal of Pain : Official Journal of the American Pain Society·Seo-Yeon YoonPatrick M Dougherty
Feb 17, 2015·Biochemical and Biophysical Research Communications·Ziyi ZhouDingfang Cai
Dec 30, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J O DavidsonA J Gunn
Jul 28, 2016·Biophysical Journal·Gemma HuguetDavid Terman
Jan 13, 2018·Frontiers in Physiology·Nunzio VicarioRosalba Parenti
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Stanley Ka-Lok LiChi-Wai Do
Aug 1, 2014·Journal of Neurophysiology·Karina GoncharenkoMichael G Fehlings
Jan 8, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sean McCutcheonMaribel Vazquez
May 11, 2017·Journal of Cellular and Molecular Medicine·Nunzio VicarioRosalba Parenti
Dec 7, 2018·Nature Biomedical Engineering·Joseph W SalatinoErin K Purcell
Feb 6, 2017·Restorative Neurology and Neuroscience·Wei ChenWusong Tong
Jun 26, 2017·Molecular Neurobiology·Paula Pierozan, Regina Pessoa-Pureur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis