Role of contrast-enhanced 18F-FDG PET/CT imaging in the diagnosis and staging of renal tumors

Nuclear Medicine Communications
Cihan GundoganMahmut G Toktaş

Abstract

The objectives of this prospective study are to compare intravenous contrast-enhanced (CE) fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CE F-FDG PET/CT) with conventional methods (CT/MRI) and to evaluate the relationship of maximum standardized uptake value (SUVmax) with Fuhrman grade in patients with renal tumors. A total of 62 patients [35 males and 27 females; mean age 55.8±12.7 (range: 27-81) years] were enrolled in the study. CE F-FDG PET/CT scanning included whole-body (early) and abdominal imaging (late) 1 and 2 h after intravenous F-FDG administration, respectively. SUVmax was calculated for primary tumors. CE F-FDG PET/CT and CT/MRI findings were compared with respect to primary tumors and staging. The sensitivity of CE F-FDG PET/CT in primary tumor detection was 98%, which was very close to that of CT/MRI (100%). CE F-FDG PET/CT resulted in correct staging in 84% of the cases, compared with 68% of the cases with conventional methods (52 vs. 42 patients). SUVmax values of early PET for the primary tumors were significantly correlated with the Fuhrman grades (P<0.001). CE F-FDG PET/CT enabled the detection of synchronous tumors in four patients, one of which was incorrectly diagnosed as having metasta...Continue Reading

References

Jul 1, 1997·Clinical Radiology·M A GoldbergM J Lee
Feb 4, 1999·AJR. American Journal of Roentgenology·S DiederichG Bongartz
Jun 6, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stefano MargaritoraPierluigi Granone
Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideDenis Agostini
Dec 19, 2003·The Urologic Clinics of North America·Nicolette K JanzenArie S Belldegrun
Oct 20, 2004·Seminars in Nuclear Medicine·Heiko Schöder, Steven M Larson
Mar 15, 2005·Seminars in Nuclear Medicine·Ignac FogelmanHans Van der Wall
Aug 26, 2006·The American Journal of Surgical Pathology·Dianne Sika-PaotonuBrett Delahunt
May 29, 2007·The American Journal of Surgical Pathology·Brett DelahuntT William Jordan
Aug 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Siew C ChuaPeter J Ell
Apr 9, 2008·Current Opinion in Oncology·Kirsten Bouchelouche, Peter Oehr
Aug 16, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Klaus StrobelThomas F Hany
Oct 31, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hsin-Yi WangChia-Hung Kao
Feb 26, 2014·Clinical Nuclear Medicine·Chiara FuccioGiuseppe Trifirò
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Emre Can PolatMustafa Ozan Horsanali

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Citations

Jun 10, 2021·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Rahul JenaAneesh Srivastava

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Methods Mentioned

BETA
biopsy
imaging techniques

Software Mentioned

CARE Dose 4D
SPSS

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