Role of Copper on Mitochondrial Function and Metabolism.

Frontiers in Molecular Biosciences
Lina M RuizAlvaro A Elorza

Abstract

Copper is essential for life processes like energy metabolism, reactive oxygen species detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather copper for the assembly of cuproenzymes such as the respiratory complex IV, cytochrome c oxidase, and the antioxidant enzyme superoxide dismutase 1. In this regard, copper plays a role in mitochondrial function and signaling involving bioenergetics, dynamics, and mitophagy, which affect cell fate by means of metabolic reprogramming. In mammals, copper homeostasis is tightly regulated by the liver. However, cellular copper levels are tissue specific. Copper imbalances, either overload or deficiency, have been associated with many diseases, including anemia, neutropenia, and thrombocytopenia, as well as tumor development and cancer aggressivity. Consistently, new pharmacological developments have been addressed to reduce or exacerbate copper levels as potential cancer therapies. This review goes over the copper source, distribution, cellular uptake, and its role in mitochondrial function, metabolic reprograming, and cancer biology, linking copper metabolism with the field of regenerative medicine and cancer.

References

Jan 1, 1977·American Journal of Hematology·B L ZidarA Winkelstein
Nov 1, 1992·The American Journal of Clinical Nutrition·P E JohnsonG I Lykken
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Aug 1, 1988·Arthritis and Rheumatism·T Matsubara, K Hirohata
Nov 1, 1986·The American Journal of Physiology·M C Linder, M Roboz
Aug 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·P GoyensS Cadranel
Apr 1, 1973·The Australian Journal of Experimental Biology and Medical Science·C H GallagherR Wright
Dec 11, 1971·The American Journal of Physiology·C A Owen
Jan 1, 1983·Acta Neuropathologica·N KochiT Itagaki
Nov 1, 1983·The American Journal of Physiology·S J KoppJ M Feliksik
May 1, 1980·The Journal of Clinical Investigation·P E Lipsky, M Ziff
Mar 1, 1995·Neurologia Medico-chirurgica·D YoshidaS Nakazawa
May 1, 1994·Preparative Biochemistry·A C Fischer, C A Goode
Jun 1, 1993·The Journal of Nutrition·B Bae, S S Percival
Jul 30, 1997·Biochemical and Biophysical Research Communications·F SoncinJ Badet
May 15, 1998·Journal of Cellular Biochemistry·G F Hu
Dec 16, 1998·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·L RossiM R Ciriolo
Apr 25, 2000·The EMBO Journal·H Schägger, K Pfeiffer
May 29, 2000·The Journal of Nutrition·Z L Huang, M L Failla
Aug 30, 2000·Human & Experimental Toxicology·N S AstonG S Evans
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·I HamzaJ D Gitlin
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·J YoshiiH Fukui
Jun 1, 2002·Current Opinion in Chemical Biology·Sergi Puig, Dennis J Thiele
Aug 1, 2002·Blood·Xylina T GreggJosef T Prchal
Jan 24, 2003·Journal of Bioenergetics and Biomembranes·Denis M Medeiros, Dianne Jennings
Jan 24, 2003·Journal of Bioenergetics and Biomembranes·Xiulian ChenDenis M Medeiros
Mar 4, 2003·Journal of Cellular and Molecular Medicine·T Wakabayashi
Apr 26, 2003·Current Opinion in Chemical Biology·George J Brewer
Jan 20, 2004·The Journal of Biological Chemistry·Paul A CobineDennis R Winge
Mar 25, 2004·Neurochemical Research·Luisa RossiGiuseppe Rotilio
May 28, 2004·Endocrine-related Cancer·V L GoodmanS D Merajver
Jan 26, 2005·Oncology Research·S A Lowndes, A L Harris
Mar 23, 2005·Archives of Otolaryngology--head & Neck Surgery·Theodoros N TeknosSofia D Merajver

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