Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation
Michael J BlahaKhurram Nasir

Abstract

Limited attention has been paid to negative cardiovascular disease (CVD) risk markers despite their potential to improve medical decision making. We compared 13 negative risk markers using diagnostic likelihood ratios (DLRs), which model the change in risk for an individual after the result of an additional test. We examined 6814 participants from the Multi-Ethnic Study of Atherosclerosis. Coronary artery calcium score of 0, carotid intima-media thickness <25th percentile, absence of carotid plaque, brachial flow-mediated dilation >5% change, ankle-brachial index >0.9 and <1.3, high-sensitivity C-reactive protein <2 mg/L, homocysteine <10 µmol/L, N-terminal pro-brain natriuretic peptide <100 pg/mL, no microalbuminuria, no family history of coronary heart disease (any/premature), absence of metabolic syndrome, and healthy lifestyle were compared for all and hard coronary heart disease and all CVD events over the 10-year follow-up. Models were adjusted for traditional CVD risk factors. Among all negative risk markers, coronary artery calcium score of 0 was the strongest, with an adjusted mean DLR of 0.41 (SD, 0.12) for all coronary heart disease and 0.54 (SD, 0.12) for CVD, followed by carotid intima-media thickness <25th percent...Continue Reading

References

Jun 28, 2002·European Journal of Epidemiology·A CiampiM Roy
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Nov 13, 2004·The Journal of Clinical Hypertension·Robert D Toto
Apr 1, 2005·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A Cecile J W JanssensEwout W Steyerberg
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Aug 21, 2008·Biostatistics·Wen Gu, Margaret Sullivan Pepe
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
May 2, 2009·The American Journal of Cardiology·Kavita SharmaKiran Musunuru
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
Mar 13, 2010·Journal of the American College of Cardiology·Harvey S Hecht
Aug 27, 2011·Journal of the American College of Cardiology·Vikas VeerannaLuis Afonso
Mar 21, 2012·Annals of Internal Medicine·Maryam KavousiJacqueline C M Witteman
Jun 4, 2013·Journal of the American College of Cardiology·Omair YousufMatthew J Budoff
Jun 5, 2013·American Journal of Epidemiology·Haitham M AhmedRoger S Blumenthal
Nov 26, 2013·Lancet·Paul M Ridker, Nancy R Cook
Mar 22, 2014·The New England Journal of Medicine·Michael J PencinaEric D Peterson
Aug 31, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Julius M GardinNathan D Wong
Sep 6, 2014·Journal of the American College of Cardiology·Kunal N KarmaliDonald M Lloyd-Jones

❮ Previous
Next ❯

Citations

May 7, 2016·Journal of the American College of Cardiology·Michael J Blaha
May 8, 2016·The American Journal of Medicine·Catherine S BennetJohn W McEvoy
Jul 5, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A L Abbott
Aug 29, 2016·JACC. Cardiovascular Imaging·Jamal S Rana, Ron Blankstein
Sep 14, 2016·The American Journal of Cardiology·Michael J Blaha
Sep 26, 2016·JACC. Cardiovascular Imaging·Michael J Blaha, Kunihiro Matsushita
Oct 8, 2016·Journal of the American College of Cardiology·Ashley PenderPhilip Greenland
Oct 16, 2016·Global Heart·Michael J BlahaPhilip Greenland
Dec 12, 2017·Risk Analysis : an Official Publication of the Society for Risk Analysis·Hans BauerBritta Herbig
Jul 7, 2017·Japanese Clinical Medicine·Shuko Nojiri, Hiroyuki Daida
Oct 5, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Aline R WageckMaurício Kunz
Feb 1, 2018·European Radiology·Daniel Bos, Maarten J G Leening
Sep 6, 2018·European Journal of Preventive Cardiology·Kazuhiro OsawaMatthew J Budoff
Oct 13, 2017·QJM : Monthly Journal of the Association of Physicians·P Rajiah, S Abbara
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Nov 2, 2016·Journal of the American Heart Association·Ysoline BeigneuxDavid Calvet
Dec 23, 2017·Journal of the American Heart Association·Teresa K ChenCarmen A Peralta
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 7, 2017·Circulation Research·Mark R Thomas, Gregory Y H Lip
Dec 3, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazuyuki YahagiRenu Virmani
Jul 24, 2018·Journal of Thoracic Imaging·Damiano CarusoAndrea Laghi
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Mar 7, 2018·MMW Fortschritte der Medizin·Sigmund Silber
Mar 7, 2019·The International Journal of Cardiovascular Imaging·Gregor S ZimmermannAlexander Becker
Apr 14, 2019·Cardiovascular Research·Lucy McShanePasquale Maffia
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Patricia MarchioMaria D Mauricio
Jul 19, 2017·BMC Cardiovascular Disorders·Ying ZhaoXiaoli Tian
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Oct 10, 2019·British Journal of Pharmacology·Marwa Daghem, David E Newby
Apr 8, 2020·Stroke; a Journal of Cerebral Circulation·Shaan KhurshidSteven A Lubitz
Jul 11, 2020·Current Opinion in Cardiology·Karan KapoorKhurram Nasir
May 15, 2020·European Journal of Clinical Investigation·Luis García-OrtizUNKNOWN on behalf EVA investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.