Role of corticosteroids in prostate cancer progression: implications for treatment strategy in metastatic castration-resistant patients

Journal of Endocrinological Investigation
S SiderisT Gil

Abstract

Corticosteroid agents (CA) are widely used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) either as concomitant treatment with active agents such as docetaxel, cabazitaxel and abiraterone or in a palliative setting, predominantly due to their anti-inflammatory activity. However, the chronic use of CA has numerous side effects, especially in case of steroid-induced adrenal insufficiency. Furthermore, the latest clinical and preclinical data demonstrate that CA themselves are likely to promote tumour progression in certain populations of patients with mCRPC. Therefore, the role of CA in advanced disease should be carefully weighed for each patient and their withdrawal should be considered in some patients. This is necessary, especially in clinical trials that need good performance status patients to evaluate the activity and the safety of emerging drugs in mCRPC that do not require the concurrent use of CA. In oncology, there is no consensus on an algorithm of gradual steroid tapering and frequently the approach to this procedure is empirical. An algorithm is presented in this article based on clinical observations. Prospective studies are necessary to evaluate the efficacy and safety of the above-pro...Continue Reading

References

Nov 1, 1989·Reviews of Infectious Diseases·A E StuckF J Frey
Sep 1, 1986·Survey of Ophthalmology·R C Urban, E Cotlier
Nov 1, 1995·Surgical Neurology·G C Szabo, S R Winkler
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I F TannockK C Murphy
Feb 15, 1997·The Journal of Clinical Investigation·M T NevalainenP L Harkonen
Jun 28, 2002·Cancer Metastasis Reviews·G BuchananW D Tilley
Nov 30, 2002·Journal of Pain and Symptom Management·Craig Gannon, Penny McNamara
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J SmallNicholas J Vogelzang
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
Sep 3, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·B M MillarN Laperriere
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 13, 2004·The Oncologist·David LussierRussell K Portenoy
Jan 28, 2005·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Ann E NahaczewskiS Hariharan
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Oct 14, 2006·Mayo Clinic Proceedings·Thomas P Warrington, J Michael Bostwick
Nov 23, 2006·The Annals of Pharmacotherapy·Kathleen A HazlewoodDonald L Harrison
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Jul 20, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ahmed Elsayem, Eduardo Bruera
Feb 8, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alina SturdzaAndrea Bezjak
Jun 7, 2008·Jornal de pediatria·Crésio AlvesMilena Mendonça
Aug 1, 2008·Endocrine-related Cancer·Meng-Lei Zhu, Natasha Kyprianou
Sep 16, 2009·Carcinogenesis·Shikhar SharmaPeter A Jones
Feb 10, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Philip J Saylor, Matthew R Smith
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
Aug 17, 2012·The New England Journal of Medicine·Howard I ScherUNKNOWN AFFIRM Investigators
Jan 1, 2010·Oncology Letters·Akira KomiyaTomohiko Ichikawa
Dec 12, 2012·The New England Journal of Medicine·Charles J RyanUNKNOWN COU-AA-302 Investigators

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Citations

Sep 18, 2016·Critical Reviews in Oncology/hematology·Giulia Baciarello, Cora N Sternberg
Mar 25, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Giorgio I RussoSandro La Vignera

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