Role of CREM in systemic lupus erythematosus

Cellular Immunology
Wang-Dong XuDong-Qing Ye

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Immune complex, autoantibodies and autoreactive lymphocytes are involved in manifestations of SLE. Recently, investigations have indicated that expression of the transcription factor cAMP responsive element modulator (CREM) is abnormal in T cells and might play an important role in the pathogenesis of SLE. CREM has much influence on the promoters, such as IL-2, c-fos, TCR ζ, and SYK. Moreover, activity of CREM itself has been demonstrated, particularly with an auto-regulatory feedback mechanism. Therefore, we will discuss the association of CREM and SLE based on current knowledge to unravel the mechanism of CREM performance.

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Citations

May 15, 2013·Rheumatology International·Wang-Dong XuDong-Qing Ye
Jul 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias D SeidlFrank U Müller

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