PMID: 8603987Feb 1, 1996Paper

Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

Journal of Leukocyte Biology
J C Lee, P R Young

Abstract

A new member of the mitogen-activated protein kinase family, alternatively termed CSBP, p38, or RK, has been identified independently by several laboratories recently. Activation of this novel protein kinase via dual phosphorylation has been observed in different cell systems upon stimulation by a wide spectrum of stimuli, such as physicochemical stress and treatment with lipopolysaccharide or proinflammatory cytokines such as interleukin-1 and tumor necrosis factor. Furthermore, CSAID cytokine biosynthesis inhibitors have now been determined to be potent and selective inhibitors of CSBP/p38/RK kinase activity. These inhibitors will help to dissect signaling pathways involved in inflammatory responses. In particular, for the first time a definitive signal transduction pathway can be prescribed to the action of lipopolysaccharide in cytokine production in macrophages.

Citations

Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·A B CarterG W Hunninghake
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·J C HedgesW T Gerthoffer
Apr 20, 2001·British Journal of Pharmacology·E B HaddadM G Belvisi
Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elaine A Irving, Mark Bamford
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Martin K AngeleIrshad H Chaudry
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leesun KimEric Y Denkers
Sep 1, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andreas Pascher, Jochen Klupp
Nov 26, 2005·Respiration; International Review of Thoracic Diseases·L LiuY Huang
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leesun KimEric Y Denkers
May 18, 2007·American Journal of Respiratory Cell and Molecular Biology·Linda A Tephly, A Brent Carter
Mar 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Linda A Tephly, A Brent Carter
Oct 18, 2008·Clinical and Vaccine Immunology : CVI·Anna LundbergMalin Fagerås Böttcher
Aug 21, 2010·Immunologic Research·Robert L Furler, Christel H Uittenbogaart
Apr 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuesong QianJianguo Liu
Jul 13, 2013·Immunopharmacology and Immunotoxicology·Qianchao WuHaihua Feng
Aug 2, 2014·Journal of Asian Natural Products Research·Wei WeiNai-Hong Chen
Nov 20, 2014·Expert Opinion on Therapeutic Patents·Peter Norman
Jan 21, 2015·Expert Opinion on Investigational Drugs·Peter Norman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.