Role of CT in Differentiating Malignant Focal Splenic Lesions

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Siwon JangJoon Koo Han

Abstract

The purpose of this study was to asses the CT findings and clinical features differentiating malignant from benign focal splenic lesions. Among 673 patients with splenectomy, we included 114 patients with pathologically confirmed focal splenic lesions (malignant = 66, benign = 48). Two radiologists retrospectively assessed CT findings including: size, number, solid component, margin, wall, calcification, contrast-enhancement, lymph node (LN) enlargement and possible malignancy. We assessed clinical features including age, sex, underlying malignancy, fever, and leukocytosis. Multivariate logistic regression analysis was performed to identify significant predictors of malignant lesion. We used receiver operating curve analysis for determination of diagnostic performance. Common findings of malignant lesions include enhanced, mainly solid, ill-defined margin, absence of splenomegaly, absence of the wall, absence of calcification, LN enlargement, and presence of underlying malignancy (p < 0.05). Among them, mainly solid features (odds ratio [OR], 39.098, p = 0.007), LN enlargement (OR, 6.326, p = 0.005), and presence of underlying malignancy (OR, 8.615, p = 0.001) were significant predictors of malignancy. The mean size of benign s...Continue Reading

References

Jul 1, 1991·European Journal of Radiology·C GoergK Goerg
Mar 1, 1994·Radiographics : a Review Publication of the Radiological Society of North America, Inc·L S RabushkaE K Fishman
May 1, 1996·AJR. American Journal of Roentgenology·F FerrozziG Garlaschi
Jan 1, 1996·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M UrrutiaP R Ros
Feb 24, 2001·European Radiology·F RobertsonO Ekberg
Jul 17, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Robert M AbbottWilliam M Thompson
Jul 13, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khaled M ElsayesJay P Heiken
Oct 20, 2006·Seminars in Ultrasound, CT, and MR·David M Warshauer, H Lee Hall
Oct 20, 2006·Seminars in Ultrasound, CT, and MR·Aya KamayaTerry S Desser
Jan 12, 2007·The Journal of Trauma·Thomas R PaluskaMichael Biondi
Feb 24, 2009·The Journal of Emergency Medicine·Akpofure Peter EkehMary C McCarthy
Aug 18, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·R K KazaI R Francis
Nov 5, 2011·Journal of the American College of Radiology : JACR·Pamela T JohnsonElliot K Fishman
Nov 19, 2011·The British Journal of Radiology·S S SabooJ P Jagannathan
Dec 5, 2012·Insights Into Imaging·Christoph A KarloHatem Alkadhi
Oct 10, 2013·Journal of Surgical Oncology·Amudhan PugalenthiT Peter Kingham
Feb 15, 2014·Abdominal Imaging·Kara Gaetke-UdagerIsaac R Francis
Sep 24, 2014·AJR. American Journal of Roentgenology·Kyung Mi JangDongil Choi

❮ Previous
Next ❯

Citations

Jan 20, 2021·Current Problems in Diagnostic Radiology·Guillermo P SangsterDavid H Ballard
Apr 10, 2021·Cancer Management and Research·Rui YangFeng Yan
May 31, 2021·Ultrasound in Medicine & Biology·Corinna TrenkerChristoph F Dietrich
Jul 20, 2021·The Journal of International Medical Research·Mihyeon ParkKil Sun Park

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.