Role of CXCR4 in HIV infection and its potential as a therapeutic target

Future Microbiology
Tsutomu Murakami, Naoki Yamamoto

Abstract

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an additional or alternative therapy to standard HAART. Among the CCR5 inhibitors developed so far, maraviroc is the first drug that has been approved by the US FDA for treating patients with R5 HIV-1. Although many CXCR4 inhibitors, some of which are highly active and orally bioavailable, have also been studied, they are still at preclinical stages or have been suspended during development. Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and pulmonary fibrosis. Therefore, CXCR4 inhibitors have potential as novel therapeutics for the treatment of these diseases as well as HIV infection.

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Citations

May 3, 2013·AIDS Research and Therapy·Edwin A HiguitaCarlos J Montoya
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Boon Chin HengMartin Fussenegger
Dec 8, 2010·Expert Opinion on Biological Therapy·Aarthi NarayananFatah Kashanchi
May 4, 2015·Bioorganic & Medicinal Chemistry Letters·Huanyu ZhaoLawrence J Wilson
Jun 26, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan ZhangYong-Tang Zheng
Sep 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charline DuquennePierre Corbeau

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Datasets Mentioned

BETA
MDA-321

Methods Mentioned

BETA
xenografts

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