Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics

Journal of Alzheimer's Disease : JAD
Florinda ListìGiuseppina Candore

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder clinically characterized by cognitive deficit with progressive worsening of memory. Recent data indicate that neurons, as well as other brain cells, can express enzymes such as cyclooxygenases (COXs) and 5-lipoxygenase (5-LO) which are considered important in inflammatory cells. Moreover, it has been demonstrated that COX-2 and 5-LO enzymes play a considerable role in the pathophysiology of AD. In order to assess the possible role of COX-2 and 5-LO single nucleotide polymorphisms (SNPs) in AD, we examined their distribution in 341 AD patients and 190 controls from Northern Italy. A significant difference was observed in the distribution of the -765G COX-2 and -1708A 5-LO alleles between AD cases and controls (p=0.03 for -765G/C COX-2 SNP; and p=0.007 for -1708G/A 5-LO SNP). Hence, COX-2 -765G and 5-LO -1708A alleles were overrepresented in AD patients and underrepresented in controls. Our data suggest that these alleles of COX-2 and 5-LO could be risk factors for AD. These results seem of some importance for a pharmacogenomic approach.

Citations

Nov 11, 2010·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
Jul 31, 2010·Cardiovascular Psychiatry and Neurology·Hari Manev, Radmila Manev
Apr 7, 2012·International Journal of Alzheimer's Disease·Ramón CacabelosMasatoshi Takeda
Jun 5, 2015·Frontiers in Cellular Neuroscience·Danira Toral-RiosVictoria Campos-Peña
May 25, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qicong ChenZunnan Huang
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Suk Ling Ma, Linda Chiu Wa Lam
Dec 15, 2012·Pharmacological Reports : PR·Grzegorz A CzapskiRobert P Strosznajder
Jun 2, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Steven P MathisBodduluri Haribabu

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