Nov 25, 2006

Role of cytokines in allergic airway inflammation

International Archives of Allergy and Immunology
Hiroshi Nakajima, Kiyoshi Takatsu


Asthma is characterized by intense infiltration of eosinophils and CD4+ T cells into the submucosal tissue of airways. Accumulating evidence indicates that T helper type 2 cell-derived cytokines such as interleukin (IL)-4, IL-5 and IL-13 play critical roles in orchestrating and amplifying allergic inflammation in asthma. In addition, it has been suggested that newly identified cytokines including thymic stromal lymphopoietin, IL-25 and IL-33 are involved in the induction of allergic inflammation in asthma. In this review, we discuss the role of individual cytokines in the pathogenesis of asthma.

  • References95
  • Citations78
  • References95
  • Citations78


Mentioned in this Paper

TSLP protein, human
Immune Response
Pathogenic Aspects
Biochemical Pathway
C19orf10 gene
IL17C gene
Recombinant Interleukin-18

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