Nov 25, 2006

Role of cytokines in allergic airway inflammation

International Archives of Allergy and Immunology
Hiroshi Nakajima, Kiyoshi Takatsu

Abstract

Asthma is characterized by intense infiltration of eosinophils and CD4+ T cells into the submucosal tissue of airways. Accumulating evidence indicates that T helper type 2 cell-derived cytokines such as interleukin (IL)-4, IL-5 and IL-13 play critical roles in orchestrating and amplifying allergic inflammation in asthma. In addition, it has been suggested that newly identified cytokines including thymic stromal lymphopoietin, IL-25 and IL-33 are involved in the induction of allergic inflammation in asthma. In this review, we discuss the role of individual cytokines in the pathogenesis of asthma.

  • References95
  • Citations78
  • References95
  • Citations78

Citations

Mentioned in this Paper

TSLP protein, human
Eosinophil
Interleukins
Immune Response
Pathogenic Aspects
Biochemical Pathway
C19orf10 gene
T-Lymphocyte
IL17C gene
Recombinant Interleukin-18

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