Role of cytokines in autoimmune myocarditis and cardiomyopathy

Autoimmunity
Y FurukawaA Matsumori

Abstract

Cellular as well as humoral autoimmune responses are critically associated with the pathogenesis and progression of myocarditis and cardiomyopathy. Cytokines appear to play critical roles in accentuating or regulating autoimmune mechanisms in these disorders. However, depending on the triggers of autoimmune responses against the heart, such as viral or parasitic infections and experimental immunization with cardiac myosin, the effect of each cytokine on autoimmune myocardial disease may vary. Cytokines may represent new therapeutic targets in the treatment and prevention of autoimmunity-mediated myocarditis and cardiomyopathy, though the etiology and variability in the type of autoimmune responses should be taken into account in the development of cytokine/anti-cytokine treatment of these disorders.

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Citations

Jun 17, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Zuyi YuanKeisuke Shioji
Jun 12, 2008·Journal of Cardiovascular Medicine·Graziella CastellanoSerafino Fazio
Dec 17, 2009·Seminars in Immunopathology·Allen W Ho, Sarah L Gaffen
Sep 29, 2011·International Journal of Cardiology·James D Fett, Charles F McTiernan
Jul 7, 2011·Clinical Lung Cancer·Gianluigi MazzoccoliRoberto Tarquini
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Aug 25, 2020·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen

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