Role of cytologic criteria in the histologic diagnosis of Gleason grade 1 prostatic adenocarcinoma

Human Pathology
J E McNealJ D Brooks

Abstract

Gleason grade 1 prostatic adenocarcinoma is defined by its gland architecture, which resembles that of benign prostate more than any other grade. It is characterized by closely spaced glands and expansile tumor border. Cytoplasm is clear to pale, superficially identical to benign nodular hyperplasia (BPH). However, there is recent evidence that prostatic "clear-cell carcinoma," including grade 1, has cytoplasm whose composition is distinctively different from BPH, being filled with lipid rather than with the protein-rich granules that characterize benign secretory cells or the nongranular protein matrix of other prostate cancers. We reasoned that grade 1 cancer might also have additional distinctive cellular features; we tested this hypothesis by observations on 17 grade 1 carcinoma foci found as components of transition zone clear-cell cancers. Unlike BPH secretory cells, cells of grade 1 cancer were uniformly large with even, straight borders laterally and luminally. Nuclei appeared sometimes benign but were fixed in a basal row dissimilar to the uneven distribution in BPH. Nuclear pyknotic foci, blue-tinged cytoplasm, and abundant dense luminal secretion were distinctively common. Immunostain for glutathione-S transferase wa...Continue Reading

References

Mar 1, 1992·Human Pathology·D F Gleason
Dec 1, 1988·The American Journal of Surgical Pathology·J E McNealT A Stamey
Sep 1, 1994·The American Journal of Surgical Pathology·P B Gaudin, J I Epstein
Jun 1, 1993·Human Pathology·C E Kramer, J I Epstein
Jul 1, 1995·The American Journal of Surgical Pathology·P B Gaudin, J I Epstein
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H LeeW G Nelson
Mar 1, 1994·Ryōikibetsu shōkōgun shirīzu·K Takaoka

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Citations

Sep 5, 2008·The American Journal of Surgical Pathology·Joaquin J GarciaSamson W Fine
Sep 10, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Sladana ZivkovićNebojsa Stojanović
May 3, 2002·The Prostate·Genevieve M VidanesJames D Brooks
Dec 24, 2005·The Prostate·Caterina MammiCostanzo Moretti
Dec 1, 2008·Surgical Pathology Clinics·Samson W Fine

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