Role of deferoxamine in tumor therapy

Acta Haematologica
A DonfrancescoA Castellano

Abstract

Several studies are consistent with the hypothesis that available iron may have some role in promoting tumor cell growth with different biological mechanisms. For this reason, several studies have been carried out to demonstrate the antitumor activity of deferoxamine (DFO), an iron chelator with a high affinity for ferritin-bound iron. In particular, the effects of DFO have been studied in patients with neuroblastoma, where ferritin is in part tumor derived and high concentrations correlate with poor outcome. To date, in vitro and in vivo studies demonstrating the antitumor effects of DFO are very promising, but further investigations are required to establish an exact role for DFO in the treatment of cancer.

Citations

Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·M KocJ Kovár
Sep 21, 2002·Biochimica Et Biophysica Acta·Nghia T V Le, Des R Richardson
Sep 15, 2001·Free Radical Biology & Medicine·F L MeyskensR I Gonzalez
Jun 7, 2002·Critical Reviews in Oncology/hematology·D R Richardson
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Jun 11, 2004·Annual Review of Nutrition·Brenda L Bohnsack, Karen K Hirschi
Sep 28, 2001·In Vitro Cellular & Developmental Biology. Animal·J KovárH Stýbrová
Nov 30, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Asta JuzenieneJohan Moan
Jan 5, 2001·Expert Opinion on Investigational Drugs·D R Richardson
Aug 25, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alessia FormigariAlessandro Santon
Dec 1, 2004·Aging Cell·Janine Hertzog SantosBennett Van Houten
Sep 29, 2004·Biochemical and Biophysical Research Communications·Martin MichaelisJindrich Cinatl
Feb 1, 1997·Pediatric Clinics of North America·O Diav-Citrin, G Koren
Dec 8, 2016·Scientific Reports·Mårten FryknäsRolf Larsson
Aug 25, 2018·Metallomics : Integrated Biometal Science·Jian WangPing Shi
Mar 26, 2019·Plastic and Reconstructive Surgery·Jeremy V LynnSteven R Buchman
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Timothy B ChastonDes R Richardson
Jan 31, 2021·Pharmaceuticals·Jacob KosyakovskyLeah R Hanson
Feb 2, 2021·Oncotarget·Gina Abdelaal, Stephany Veuger
Oct 1, 2004·Journal of Medicinal Chemistry·Hyun-Soon ChongMartin W Brechbiel

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