Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.

The Journal of Biological Chemistry
Veronica NinEduardo N Chini

Abstract

The NAD(+)-dependent deacetylase SIRT1 is a key regulator of several aspects of metabolism and aging. SIRT1 activation is beneficial for several human diseases, including metabolic syndrome, diabetes, obesity, liver steatosis, and Alzheimer disease. We have recently shown that the protein deleted in breast cancer 1 (DBC1) is a key regulator of SIRT1 activity in vivo. Furthermore, SIRT1 and DBC1 form a dynamic complex that is regulated by the energetic state of the organism. Understanding how the interaction between SIRT1 and DBC1 is regulated is therefore essential to design strategies aimed to activate SIRT1. Here, we investigated which pathways can lead to the dissociation of SIRT1 and DBC1 and consequently to SIRT1 activation. We observed that PKA activation leads to a fast and transient activation of SIRT1 that is DBC1-dependent. In fact, an increase in cAMP/PKA activity resulted in the dissociation of SIRT1 and DBC1 in an AMP-activated protein kinase (AMPK)-dependent manner. Pharmacological AMPK activation led to SIRT1 activation by a DBC1-dependent mechanism. Indeed, we found that AMPK activators promote SIRT1-DBC1 dissociation in cells, resulting in an increase in SIRT1 activity. In addition, we observed that the SIRT1 a...Continue Reading

References

Oct 24, 2001·Cell·H VaziriR A Weinberg
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Guoqiang Jiang, Bei B Zhang
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Aug 28, 2003·The Journal of Biological Chemistry·Wu YinMorris J Birnbaum
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Sep 24, 2004·The Journal of Biological Chemistry·Javier R RevolloShin-ichiro Imai
Mar 8, 2005·The Journal of Biological Chemistry·Margie T BorraJohn M Denu
Mar 23, 2005·Current Opinion in Cell Biology·D Grahame Hardie
Dec 22, 2005·PLoS Biology·Laura BordoneLeonard Guarente
May 30, 2006·Biochemical and Biophysical Research Communications·Pinar AksoyEduardo N Chini
Aug 29, 2006·Biochemical and Biophysical Research Communications·Pinar AksoyEduardo N Chini
Feb 3, 2007·Current Opinion in Gastroenterology·Javier R RevolloShin-ichiro Imai
Feb 20, 2007·The Journal of Biological Chemistry·Eric van der VeerJ Geoffrey Pickering
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver
May 3, 2007·Molecular Endocrinology·Amy M TrauernichtThomas G Boyer
Jun 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Thereza P BarbosaEduardo Nunes Chini
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joseph T Rodgers, Pere Puigserver
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R GledhillJohn E Walker
Aug 23, 2007·The Journal of Biological Chemistry·Eric L GreerAnne Brunet
Feb 1, 2008·Nature·Ja-Eun KimZhenkun Lou
Feb 1, 2008·Nature·Wenhui ZhaoWei Gu
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Jun 5, 2008·Science Signaling·Andrew J Murray
Jun 14, 2008·Genes & Development·Danica ChenLeonard Guarente
Dec 25, 2008·PloS One·Tsutomu SasakiHeidi Scrable
Feb 25, 2009·Biochemical and Biophysical Research Communications·Barbara Zschoernig, Ulrich Mahlknecht

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Citations

Apr 17, 2013·Apoptosis : an International Journal on Programmed Cell Death·Sun Hee ParkSteven M Frisch
May 16, 2013·Cancer Metastasis Reviews·Ming ShiNing Guo
Jan 30, 2013·Molecular Aspects of Medicine·Carles CantóPeter Bai
Sep 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa A SuterKjersti M Aagaard
Sep 4, 2013·Journal of Molecular Endocrinology·Keir Menzies, Johan Auwerx
Feb 23, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Antje Bruckbauer, Michael B Zemel
Jan 23, 2015·BioMed Research International·Jessica BrunquellBin Xue
Aug 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wootae KimJa-Eun Kim
Jan 24, 2015·Diabetes·Salmaan Ahmed KhanDouglas G Mashek
Jan 21, 2016·Oxidative Medicine and Cellular Longevity·Leonardo SantosAna Denicola
Feb 17, 2015·Obesity·José María Moreno-NavarreteJosé Manuel Fernández-Real
Aug 19, 2014·Journal of Hepatology·Zheng Yun ZhangSung Joo Kim
Jun 26, 2014·International Journal of Cancer. Journal International Du Cancer·Jun Sang BaeKyu Yun Jang
Jul 1, 2015·Current Biology : CB·Natalie J German, Marcia C Haigis
Mar 4, 2015·Cell Reports·Bo QinZhenkun Lou
Nov 21, 2013·Experimental Neurology·Aldo CalliariEduardo N Chini
Dec 4, 2013·Biochimica Et Biophysica Acta·Maiko Suzuki, John D Bartlett
Apr 2, 2013·Free Radical Biology & Medicine·Jae-woong HwangIrfan Rahman
Jul 12, 2013·Bioscience Reports·Eduardo Nunes ChiniCarlos Escande
Feb 26, 2014·Molecular Metabolism·Marie Boutant, Carles Cantó
Oct 16, 2014·Biochimica Et Biophysica Acta·Sameer S Kulkarni, Carles Cantó
Dec 31, 2014·Cellular and Molecular Life Sciences : CMLS·Jacob L Bitterman, Jay H Chung
Nov 4, 2016·Asian-Australasian Journal of Animal Sciences·Qiong LiQingwu W Shen
Dec 15, 2015·Molecular & Cellular Proteomics : MCP·Sophie S B GiguèreIleana M Cristea
Oct 18, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Li LiuJena J Steinle
Jan 9, 2019·Journal of Molecular Endocrinology·Ayse Basak EnginIpek Isik Gonul
Jan 15, 2015·Molecular Medicine·Lili KongLu Cai
Jan 24, 2014·The Journal of Biological Chemistry·Di ShaoMarkus M Bachschmid
Apr 19, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Guillermo A Silva-MartínezGertrud Lund

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