Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation

Immunological Investigations
Ulrike KammererSandra M Blois

Abstract

Successful mammalian pregnancy relies on the action of sophisticated regulatory mechanisms that allow the fetus (a semi-allograft) to grow and develop in the uterus in spite of being recognized by maternal immune cells. Among several immunocompetent cells present at the maternal fetal interface, dendritic cells (DC) seem to be of particular relevance for pregnancy maintenance given their unique ability to induce both antigen-specific immunity and tolerance. Thus, these cells would be potentially suitable candidates for the regulation of local immune responses within the uterus necessary to meet the difficult task of protecting the mother from infection without compromising fetal survival. Current evidence on decidual DC phenotype and function, and their role in the regulation of the maternal immune system during mouse and human pregnancy are discussed and reviewed herein; highlighting novel DC functions that seem to be of great importance for a successful pregnancy outcome.

Citations

Sep 17, 2009·Immunology and Cell Biology·Nicola F LintonChandrakant Tayade
Jun 24, 2014·Cellular & Molecular Immunology·Ester Leno-DuránIrene Tirado-González
Sep 29, 2012·Immunological Investigations·Jamie L Harden, Nejat K Egilmez
Sep 8, 2011·Expert Review of Clinical Immunology·Elisa Tagliani, Adrian Erlebacher
Jun 8, 2012·American Journal of Reproductive Immunology : AJRI·Tsvetelina OreshkovaMilena Mourdjeva
Sep 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leigh A JonesCraig W Roberts
Apr 9, 2020·Frontiers in Immunology·Yongbo ZhaoLiping Jin
Apr 3, 2012·American Journal of Reproductive Immunology : AJRI·Dorota A Darmochwal-KolarzJan Oleszczuk
Mar 23, 2012·The Journal of Obstetrics and Gynaecology Research·Mahmood BozorgmehrSeyed Mohammad Moazzeni
Nov 3, 2009·Journal of Reproductive Immunology·G BarrientosS M Blois
Jan 14, 2011·Journal of Reproductive Immunology·Sandra M BloisGabriela Barrientos

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