Role of dexmedetomidine in early extubation of the intensive care unit patients

Journal of Anaesthesiology, Clinical Pharmacology
Shikha GuptaSuneet Kathuria

Abstract

Patients on ventilatory support in intensive care unit (ICU) require sedation and analgesia to facilitate mechanical ventilation and endotracheal tube tolerance. The selection of the agent should be such that it does not interfere with the early extubation of the patients. We compared the efficacy of dexmedetomidine with midazolam to facilitate extubation of patients from mechanical ventilation in terms of the sedative properties, cardiovascular responses, ventilation, and extubation characteristics and safety profile. A total of 40 adult, mechanically ventilated patients of either sex, aged 18-60 years, meeting the standard criteria for weaning, randomized into 2 groups of 20 patients each, received intravenous infusion of dexmedetomidine (0.2-0.7 mcg/kg/h) or midazolam (0.04-0.2 mg/kg/h) as needed for Ramsay sedation scale 2-4. Extubation following standard extubation protocol was done. Time for extubation and vital parameters were regularly recorded. The time to extubation in the dexmedetomidine group was significantly lower than in the midazolam group. Heart rate and blood pressure was significantly lower in dexmedetomidine group than the midazolam group at most of the times. Dexmedetomidine has clinically relevant benefits...Continue Reading

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Citations

Sep 20, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Carly Peterson, Michael Hall
Aug 21, 2016·The Annals of Pharmacotherapy·M Alexandra SchickliPatrick D Ratliff
Apr 7, 2018·Critical Care Research and Practice·Hatem Elmoutaz Mahmoud, Doaa Abou Elkassim Rashwan
Jun 18, 2020·Frontiers in Pediatrics·Utpal S BhalalaElumalai Appachi

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Methods Mentioned

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