Role of diabetes in the prognosis and therapeutic outcome of tuberculosis.

International Journal of Endocrinology
Syed Azhar Syed SuleimanMohamed A A Moussa

Abstract

Background. Increased susceptibility of diabetic mellitus (DM) patients to infection, including tuberculosis (TB), is well documented. The prevalence of DM in Malaysia is reaching epidemic proportions. In this study, we sought to assess risk factors for TB and the impact of DM on the outcome of TB treatment. Methods. TB patients, diabetic patients, and diabetic patients with TB were divided into three groups of 200 subjects each. Data were obtained from patients' medical files at the beginning and end of the study period. Prevalence rates of DM and HIV among TB patients were assessed. Prognosis, TB-related complications, anatomical site of infection, and duration of infection and diabetes were also examined. Results. The prevalence rates of HIV and DM amongst TB patients were 7.7 and 30%, respectively. The diabetic TB patient group contained more males (72%) and smokers (45.5%) compared to the nondiabetic group (58.3% and 33.5%, resp.). Approximately 74% of diabetic patients were Mycobacterium sputum positive compared to only 51% of nondiabetic patients. Diabetic patients were also more likely to develop pulmonary TB (87%) compared to nondiabetic TB patients (59%). Diabetic TB patients had a higher mortality rate (7.5%) compare...Continue Reading

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Citations

May 9, 2014·Current Diabetes Reports·Marit Eika Jørgensen, Daniel Faurholt-Jepsen
Mar 28, 2013·The American Journal of the Medical Sciences·Syed Azhar Syed SulaimanMohamed Azmi Hassali
Jun 20, 2015·Indian Journal of Clinical Biochemistry : IJCB·Kirtimaan SyalDibyajyoti Banerjee
Mar 1, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chi C LeungCheuk M Tam
Oct 17, 2018·Reviews on Environmental Health·Nur Adibah MohidemPunitha Makeswaran
Sep 12, 2019·Ciência & saúde coletiva·Marcelle Lemos LealNágela Valadão Cade
Oct 5, 2019·Journal of Immunology Research·Birhanu AyelignTewodros Shibabaw

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Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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