Role of Diagnostic 131 I SPECT/CT in Long-Term Follow-up of Patients with Papillary Thyroid Microcarcinoma

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Angela SpanuGiuseppe Madeddu

Abstract

Papillary thyroid microcarcinoma (PTMC) usually has a favorable prognosis but can also be aggressive, with neck and distant metastases. We evaluated the diagnostic role of 131I SPECT/CT in detecting metastases in PTMC patients during long-term follow-up and whether the procedure should be included in the current diagnostic protocol. Methods: We retrospectively studied 351 consecutive PTMC patients who had undergone thyroidectomy and radioiodine therapy; 21 were at high risk, 94 at low risk, and 236 at very low risk. During follow-up, the patients underwent diagnostic 131I whole-body scanning (WBS) followed by SPECT/CT. Results: WBS found 248 radioiodine-avid foci in 126 patients, and SPECT/CT found 298 in 139 patients, confirming all foci found on WBS. SPECT/CT also correctly classified 76 of the avid foci as unclear or wrongly classified on WBS. Globally, SPECT/CT detected and correctly classified 64 neoplastic lesions in 27 of 30 patients with metastases, and WBS evidenced 39 of 64 lesions, 28 of which were unclear or wrongly classified, in 16 of the 30 patients. Nineteen of 27 patients, including 13 at very low risk, had only neck metastases, 9 of 19 being T1aN0M0 with an undetectable thyroglobulin level. Three of 27 patient...Continue Reading

References

Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A BelfioreR Vigneri
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·W LangstegerO Eber
Sep 1, 1988·Clinical Nuclear Medicine·J H Miller, C S Marcus
Jun 29, 2004·European Journal of Nuclear Medicine and Molecular Imaging·K TharpD Delbeke
Feb 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Elio RotiEttore C Degli Uberti
May 27, 2006·European Journal of Endocrinology·Furio PaciniUNKNOWN European Thyroid Cancer Taskforce
Sep 4, 2007·European Journal of Endocrinology·Yukiko YanoKoichi Ito
Dec 21, 2007·Nuclear Medicine Communications·Laura J SawyerMartyn J Evans
Jan 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Angela SpanuGiuseppe Madeddu
Apr 8, 2009·Thyroid : Official Journal of the American Thyroid Association·Giuseppe MercanteVerter Barbieri
Apr 2, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Mona MustafaDaniela Schmidt
May 23, 2012·Clinical Nuclear Medicine·Mareen MengesDaniela Schmidt
Feb 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Anca M AvramKa Kit Wong
May 6, 2014·World Journal of Surgery·Tracy S WangSanziana A Roman
Sep 14, 2014·Endocrine-related Cancer·G AziziC D Malchoff
Jul 3, 2015·Experimental and Therapeutic Medicine·Wei ZhengGuizhi Zhang

❮ Previous
Next ❯

Citations

Nov 6, 2021·The International Journal of Biological Markers·Xiaohui WenXun Wang
Nov 27, 2021·The International Journal of Biological Markers·Ligia C A Cardoso-DuarteIzabel Cristina R Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved