Role of dietary onion in modifying the faecal bile acid content in rats fed a high-cholesterol diet

Food & Function
Diana González-PeñaConcepción Sánchez-Moreno

Abstract

The determination of faecal bile patterns offers new opportunities in the search for non-invasive biomarkers of disease status. The objective of this study was to describe the shifts in faecal bile acid (BA) composition induced by feeding a high-cholesterol/cholic acid diet (HC) over 7 weeks of experimental feeding in Wistar rats, and to evaluate the effect of onion included as a functional ingredient (HCO). A HPLC-MS/MS method allowed the detection of 29 bile acids, 10 of which were tentatively identified and 12 confirmed and quantified by means of standards and calibration curves. The excretion of bile acids revealed a discriminating bile acid profile between the HC and HCO groups compared with the C group. HCO feeding indicated significant changes in specific primary and secondary BA in both the unconjugated and conjugated forms caused by the addition of the onion ingredient to the diet. The results suggest that the induction of microbiome modifications by the HC and HCO diets acts as a critical modifier of the faecal bile acid composition. These modifications might reflect and be linked to changes in the reabsorption of BA at an intestinal level and the process of BA deconjugation in the course of hypercholesterolemia.

References

May 1, 1997·The Journal of Nutrition·P G Reeves
Apr 5, 2005·The Journal of Veterinary Medical Science·Won-Il JeongKyu-Shik Jeong
Jul 5, 2005·Biochimica Et Biophysica Acta·Charlotte MurphyMats Gåfvels
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naoto MatsuzawaShuichi Kaneko
May 31, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ivana BobeldijkElwin Verheij
Sep 6, 2008·Journal of Lipid Research·Masahito HagioSatoshi Ishizuka
Apr 7, 2009·Journal of Lipid Research·John Y L Chiang
Feb 16, 2010·Metabolism: Clinical and Experimental·Satyakumar VidyashankarKrishnapura Srinivasan
Jul 31, 2010·Journal of Lipid Research·Youcai Zhang, Curtis D Klaassen
Dec 4, 2010·Journal of Agricultural and Food Chemistry·Yuan-Yen ChangYi-Chen Chen
Aug 16, 2011·Gastroenterology·K B M Saiful IslamAtsushi Yokota
Jan 16, 2013·Advances in Nutrition·Lee R Hagey, Matthew D Krasowski
Jan 31, 2014·Journal of Diabetes and Metabolic Disorders·Abbas Mohammadi, Ebrahim Abbasi Oshaghi
Mar 15, 2014·Current Opinion in Gastroenterology·Jason M RidlonJasmohan S Bajaj
Dec 24, 2014·Journal of Basic and Clinical Physiology and Pharmacology·Stephen M Suru, Chidiebere E Ugwu
Jan 15, 2015·Toxicology and Applied Pharmacology·Peizhen SongCurtis D Klaassen
Apr 1, 2016·Current Opinion in Lipidology·Marleen SchonewilleAlbert K Groen
Apr 26, 2016·Journal of Applied Microbiology·M-Y ParkM-K Sung

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Citations

Jan 14, 2018·Scientific Reports·Tariq Jamal KhanMuhammad Yasir
Mar 13, 2021·International Journal of Experimental Pathology·Luiza Ferracini CunhaAlethea Gatto Barschak

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