PMID: 9533644Apr 9, 1998Paper

Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract

Peptides
E MilushevaG Varga

Abstract

Mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) are known to increase the motility of different segments in the gut. The present study was carried out to identify the bombesin receptor subtypes mediating the contractions induced by exogenous bombesin-like peptides in muscle strips isolated from cat esophagus, fundus, and duodenum. Both GRP-10 and NMB evoked concentration-dependent contractions in circular strips of esophagus and fundus and in longitudinal strips of the duodenum. These contractions were tetrodotoxin- and atropine-resistant. The potency of NMB in esophageal strips was 33 times higher than that of GRP-10. The NMB-preferring receptor antagonists D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2 (SSocta) and D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127) shifted the NMB and GRP concentration-response curves to the right, while the GRP-preferring receptor antagonist [D-Phe6]Bombesin(6-13)-methyl-ester (BME) did not affect the response to the peptides. Isolated muscle strips from the cat fundus and duodenum showed a higher sensitivity to GRP-10 than to NMB. In both segments, BME shifted the GRP-10 and NMB concentration-response curves to the right, while SSocta had no effect....Continue Reading

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Citations

Mar 22, 2002·European Journal of Pharmacology·Sarah MasonShaun McNulty
Jul 29, 1999·Journal of Hepatology·L BaiocchiG Alpini
Jun 7, 2000·Progress in Neurobiology·H Ohki-Hamazaki
Apr 25, 2000·Molecular and Cellular Biology·R L BoshansC D'Souza-Schorey
Jan 5, 2002·Canadian Journal of Physiology and Pharmacology·V C SmithA M Buchan
Jan 6, 2016·The Journal of Pharmacology and Experimental Therapeutics·Takahiro ShimizuMotoaki Saito
May 16, 2015·Peptides·Irene Ramos-ÁlvarezRobert T Jensen
Aug 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider
Apr 13, 2006·World Journal of Gastroenterology : WJG·Sung-Uk ParkUy-Dong Sohn
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J B KimJ M Conlon

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