Role of Diffusion-weighted and Contrast-enhanced Magnetic Resonance Imaging in Differentiating Activity of Ankylosing Spondylitis

Chinese Medical Journal
Ying-hua ZhaoShao-lin Li

Abstract

Previous studies showed that combining apparent diffusion coefficient (ADC) value with the Spondyloarthritis Research Consortium of Canada (SPARCC) index value might provide a reliable evaluation of the activity of ankylosing spondylitis (AS), and that contrast-enhanced (CE) magnetic resonance imaging (MRI) is unnecessary. However, the results were based on confirming only a small random sample. This study aimed to assess the role of CE-MRI in differentiating the disease activity of AS by comparing ADC value with a large sample. A total of 115 patients with AS were enrolled in accordance with Bath AS Disease Activity Index and laboratory indices, and 115 patients were divided into two groups, including active group (n = 69) and inactive group (n = 46). SPARCC, ΔSI, and ADC values were obtained from the short tau inversion recovery (STIR), diffusion-weighted imaging (DWI), and CE-MRI, respectively. One-way analysis of variance and receiver operating characteristic analysis were performed for all parameters. The optimal cutoff values (with sensitivity, specificity, respective area under the curve, positive likelihood ratio, and negative likelihood ratio) for the differentiation between active and inactive groups are as follows: S...Continue Reading

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Citations

Aug 14, 2018·Journal of Magnetic Resonance Imaging : JMRI·Fengxian WangZhengyang Zhou
Nov 5, 2019·The Journal of Rheumatology·Catherine BakewellGurjit S Kaeley
Mar 17, 2020·Advances in Rheumatology·Gustavo Gomes ResendePercival Degrava Sampaio-Barros
Oct 23, 2018·F1000Research·Leticia Garcia-MontoyaPaul Emery

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Methods Mentioned

BETA
ESR

Software Mentioned

MedCalc
SPSS

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