Role of diffusion-weighted imaging in distinguishing thoracoabdominal neuroblastic tumours of various histological types and differentiation grades

Journal of Medical Imaging and Radiation Oncology
Yang WenNan Zhang

Abstract

Diffusion-weighted MR imaging (DWI) has demonstrated a great potential to help distinguish benign from malignant tumours in paediatric body. Our purpose is to evaluate whether DWI allow discrimination of thoracoabdominal neuroblastic tumours of various histological types and differentiation grades. We retrospectively analysed DWI scans of the thoracoabdominal neuroblastic tumours in 25 children (11 girls, 14 boys). DWI was performed with two b-values of 0 and 800 s/mm2 on a 3.0T MR scanner. The apparent diffusion coefficient (ADC) values of different classifications of tumours were compared with Independent-Samples T Test. In the 25 cases, ganglioneuroma (GN) was in 3 cases, ganglioneuroblastoma (GNB) in 7 (GNB-Intermixed in 4, GNB-Nodular in 3) and neuroblastoma (NB) in 15. In three cases of GNB-Nodular, two cases had poorly differentiated nodules and another had differentiated nodules. In 15 cases of NB, poorly differentiated, differentiated and undifferentiated tumours were, respectively, in eight, five and two cases. The ADC value of the NB was significantly lower than that of GN/GNB (P < 0.001). The ADC of GNB-Nodular/NB was significantly less than that of GN/GNB-Intermixed (P < 0.0001). In GNB-Nodular/NB detection, there ...Continue Reading

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Citations

Aug 6, 2018·Pediatric Radiology·Alan M ChenAlexander J Towbin
Dec 8, 2020·Journal of Magnetic Resonance Imaging : JMRI·Laura PriviteraStefano Giuliani

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