PMID: 9546943Jan 1, 1997Paper

Role of digital artery adrenoceptors in Raynaud's disease

Vascular Medicine
J P CookeM A Creager

Abstract

Raynaud's disease is characterized by excessive cutaneous vasoconstriction in response to ambient cold. A functional disturbance in the local regulation of digital vasomotion has been proposed. The purpose of this study was to determine whether there is an alteration in the postjunctional adrenergic receptors in the digital circulation of patients with Raynaud's disease. Furthermore, we sought to determine whether this abnormality was responsible for the excessive cold-induced vasoconstriction in these patients. Finger blood flow was measured by strain-gauge venous occlusion plethysmography in 10 patients with Raynaud's disease and in 10 normal volunteers in a 22 degrees C room. Measurements of finger blood flow and mean systemic arterial pressure were made during intra-arterial infusions of the alpha 1-adrenergic antagonist, prazosin, or the alpha 2-adrenergic antagonist, yohimbine, at room temperature and during local cooling of the hand. Basal finger blood flow in normal subjects was significantly greater than that of patients (8.6 +/- 2.7 vs 1.7 +/- 0.5 ml/100 ml per min; normal vs Raynaud's subjects; p < 0.05). In normal subjects, either prazosin or yohimbine induced dose-dependent increases in finger blood flow. The maxim...Continue Reading

References

Nov 1, 1990·Circulation·J P CookeJ T Shepherd
Jun 1, 1988·European Journal of Clinical Investigation·J D Coffman, R A Cohen
Oct 1, 1986·Acta Physiologica Scandinavica·L E Lindblad, L Ekenvall
Nov 1, 1970·The American Journal of Physiology·R F ScottM Kroms
May 1, 1984·Circulation Research·J P CookeP M Vanhoutte

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Citations

Oct 20, 2005·Clinical Science·Nancy L Kanagy
Dec 24, 2014·Nature Reviews. Rheumatology·Nicholas A Flavahan
Feb 1, 2006·Vascular Medicine·John P Cooke, Janice M Marshall
Mar 3, 2005·Rheumatology·A L Herrick
Nov 24, 2011·Pain Research and Treatment·Charles J Vierck
Nov 24, 2011·Cardiology Research and Practice·Audrey DooleyDavid J Abraham

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