Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review).

International Journal of Oncology
D B Zimonjic, N C Popescu

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death, and its incidence is increasing worldwide in an alarming manner. The development of curative therapy for advanced and metastatic HCC is a high clinical priority. The HCC genome is complex and heterogeneous; therefore, the identification of recurrent genomic and related gene alterations is critical for developing clinical applications for diagnosis, prognosis and targeted therapy of the disease. This article focuses on recent research progress and our contribution in identifying and deciphering the role of defined genetic alterations in the pathogenesis of HCC. A significant number of genes that promote or suppress HCC cell growth have been identified at the sites of genomic reorganization. Notwithstanding the accumulation of multiple genetic alterations, highly recurrent changes on a single chromosome can alter the expression of oncogenes and tumor suppressor genes (TSGs) whose deregulation may be sufficient to drive the progression of normal hepatocytes to malignancy. A distinct and highly recurrent ...Continue Reading

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Citations

May 13, 2014·PloS One·Chong WangZhiqun Min
Nov 8, 2013·Cellular and Molecular Life Sciences : CMLS·Maaike H Oosterveer, Kristina Schoonjans
Jan 28, 2014·Biochemical and Biophysical Research Communications·Fangyi LiLizhi Bai
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Aug 10, 2017·Oncology Letters·Liming WuShusen Zheng
Aug 28, 2020·Scientific Reports·Daniel MorganErik L L Sonnhammer

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Methods Mentioned

BETA
genotyping
GTPase
GTPases
xenografting
two-hybrid
chromosomal aberrations
transgenic
xenografts

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