Role of donor HLA class I mismatch, KIR-ligand mismatch and HLA:KIR pairings in hematological malignancy relapse after unrelated hematopoietic stem cell transplantation

HLA : Immune Response Genetics
Elzbieta Graczyk-PolJacek Nowak

Abstract

HLA are functional in cancer immunosurveillance in adaptive and innate immunity pathways. In unrelated hematopoietic stem cell transplantation (HSCT) in 688 patients with hematological malignancies we compared antitumor efficacy of transplant in three models including the level of: (a) donor-recipient HLA class I mismatch, (b) KIR-ligand mismatch, (c) post-transplant cognate HLA:KIR pairing. The effects were directly compared in multivariate models with backward elimination including all three effects in initial model. In final multivariate model HLA mismatch and KIR-ligand mismatch levels were eliminated and HLA:KIR-dependent NK cell licensing effect remained independent prognostic factor for DFS, relapse/progression incidence, and overall survival (OS). These results suggested that NK cell licensing via cognate HLA:KIR pairs is primarily functional in cancer immunosurveillance in HSCT.

References

Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Aug 12, 2006·Immunity·Nicolas AnfossiEric Vivier
Nov 26, 2008·Bone Marrow Transplantation·J Nowak
Sep 8, 2010·The Journal of Experimental Medicine·Nathalie T JonckerDavid H Raulet
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·L Michael ThomasEric O Long
Jul 22, 2014·American Journal of Hematology·Jacek NowakUNKNOWN Polish Donor-Recipient Matching Study Group
Dec 19, 2014·Blood·Yasuo MorishimaUNKNOWN Japan Marrow Donor Program
Jan 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jacek NowakUNKNOWN Polish Donor-Recipient Matching Study Group
Dec 10, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Marta Rogatko-KorośJacek Nowak

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