Role of dopamine D1 receptors and extracellular signal regulated kinase in the motivational properties of acetaldehyde as assessed by place preference conditioning

Alcoholism, Clinical and Experimental Research
Liliana SpinaE Acquas

Abstract

The role of dopamine D1 receptors and Extracellular signal Regulated Kinase (ERK) in the motivational properties of drugs can be studied by place-conditioning. Recent advances have shown that the motivational properties of ethanol, determined by place-conditioning, are mediated by its metabolic conversion into acetaldehyde. To date, the role of D1 receptors and ERK activation in acetaldehyde-elicited place preference has not been determined. The aim of this study was to assess the role of D1 receptors blockade and MEK inhibition in the acquisition of acetaldehyde-elicited conditioned place preference. Male Sprague-Dawley rats were subjected to repeated pairings with 1 compartment of the conditioning apparatus immediately following acetaldehyde (20 mg/kg i.g.) or ethanol (1 g/kg i.g.) administration. The D1 receptor antagonist, SCH 39166 (50 microg/kg s.c.), was administered 10 minutes before acetaldehyde or ethanol administration. In order to study the role of activated ERK in the acetaldehyde-elicited place preference, rats were administered the MEK inhibitor, PD98059 (1, 30, and 90 microg i.c.v.), 10 or 30 minutes before acetaldehyde. To verify the specificity of these effects, we also studied whether PD98059 pretreatment cou...Continue Reading

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Citations

Mar 24, 2012·Alcohol·Alessandra T PeanaMarco Diana
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Allison C Hoffman, Sarah E Evans
Jul 30, 2014·Neuroscience and Biobehavioral Reviews·Katharine A BrennanPenelope Truman
Nov 29, 2016·Journal of Experimental Neuroscience·Alessandra T PeanaElio Acquas
Apr 5, 2018·Frontiers in Behavioral Neuroscience·In Soo RyuEun Sang Choe
Mar 3, 2020·Frontiers in Pharmacology·Laxman SinghAtanas G Atanasov
Feb 25, 2017·Frontiers in Behavioral Neuroscience·Anna BrancatoCarla Cannizzaro
May 30, 2017·Frontiers in Behavioral Neuroscience·Alessandra T PeanaElio Acquas

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