Role of dopamine in the inhibitory control of growth hormone and prolactin release by gastrin-releasing peptide

Brain Research Bulletin
S Kentroti, S M McCann

Abstract

The ability of gastrin-releasing peptide to inhibit the release of growth hormone and prolactin by a hypothalamic mechanism has been previously reported. To determine whether or not these effects involved the hypothalamic dopaminergic neurons, ovariectomized female rats were pretreated with the dopamine receptor blocker, pimozide (0.6 mg/kg, SC), or the diluent 35 min prior to administration of gastrin-releasing peptide (2 micrograms in 2 microliters 0.9% NaCl) into the third ventricle. The elevation in plasma growth hormone in response to growth hormone-releasing factor (GRF; 1 microgram/kg, i.v.) was blocked by gastrin-releasing peptide as previously reported following pretreatment with the diluent, but occurred following the injection of pimozide, reversing the inhibitory action of gastrin-releasing peptide. Some control animals that were injected with the pimozide vehicle exhibited elevated plasma prolactin levels compared to levels in uninjected controls. Gastrin-releasing peptide significantly lowered plasma prolactin concentrations in this group of animals. As expected, plasma prolactin levels were elevated following pimozide treatment due to the removal of inhibitory dopaminergic control. Prolactin concentrations were u...Continue Reading

References

Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S KentrotiS M McCann
Mar 1, 1974·Journal of Applied Physiology·P G Harms, S R Ojeda
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J Antunes-Rodrigues, S M McCann
May 1, 1984·Peptides·E WiderlövG R Breese
Jan 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·N MatsushitaH Imura
Mar 1, 1982·Physiology & Behavior·P J KulkoskyG P Smith
Apr 28, 1980·Brain Research·Y TachéM Brown

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Citations

Feb 11, 2003·Peptides·Kouji MatsumotoKeiji Wada
Mar 30, 2011·Medical Hypotheses·Bianca Lee Negrao, Margaretha Viljoen
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy

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