Role of dopamine receptors in the dual effect of naloxone on quinpirole-induced yawning in morphine pretreated rats

Naunyn-Schmiedeberg's Archives of Pharmacology
A ZharkovskyL Ahtee


The present study was undertaken to determine the state of sensitivity of dopamine D2/D3 receptors involved in the mediation of yawning behaviour at various times following acute morphine administration to rats. Morphine (3.0 mg/kg, s.c.) induced a biphasic effect on locomotor activity: an initial inhibitory phase lasting for about 30 min was after about an hour followed by a phase of locomotor activation lasting for about 60 min. Dopamine D2/D3 receptor agonist quinpirole (0.01-0.1 mg/kg, s.c.) induced yawning behaviour in rats. Morphine given at 15 or 60 min before (inhibitory phase) inhibited the yawning response to quinpirole (0.1 mg/kg) but not when given at 90 or 120 min before (stimulatory phase). Naloxone (1.0 mg/kg) given 10 min before quinpirole restored yawning inhibited by morphine pretreatment during the inhibitory phase (15-60 min after morphine). However, during the morphine-induced stimulatory phase naloxone strongly inhibited the yawning response to quinpirole. D1 receptor antagonist SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3- benzazepin-7-ol hemimaleate] at 0.01 mg/kg did not affect quinpirole-induced yawning or its inhibition by morphine. However, in rats which received morphine 90 mi...Continue Reading


Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·E Mogilnicka, V Klimek
Jun 18, 1979·Life Sciences·S de la BaumeJ C Schwartz
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·K R Carlson, J Almasi
Jan 1, 1990·Journal of Neural Transmission. General Section·K YamadaT Furukawa
Apr 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·A M Zarkovsky, K S Cereska
Mar 29, 1988·European Journal of Pharmacology·M VasseP Protais
Dec 10, 1985·European Journal of Pharmacology·J R Martin, A E Takemori
Jan 1, 1987·Psychopharmacology·R LongoniG Di Chiara
Mar 17, 1987·European Journal of Pharmacology·J R Martin, A E Takemori
Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·H G Möller, K Kuschinsky
Jan 21, 1986·European Journal of Pharmacology·G SerraG L Gessa
Jan 1, 1986·Neuroendocrinology·H H Berendsen, A J Gower
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Jan 1, 1982·Neurochemistry International·U Havemann, K Kuschinsky


Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J F Dixon, L E Hokin

Related Concepts

Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Dopamine Receptor
Dopamine Effect
Rats, Wistar

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.