Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle

Journal of Human Reproductive Sciences
Neeta SinghP Vanamail

Abstract

This study was performed to assess the prognostic value of serum beta human chorionic gonadotropin (βhCG), measured on day 14 post embryo transfer (ET) for predicting multiple gestation and pregnancy wastage in women undergoing in vitro fertilization ET (IVF-ET). This retrospective study was performed between May 2009 and November 2012. Out of the 181 women who conceived, 168 were included and the remaining 13 were excluded as their pregnancy was biochemical. Serum βhCG was measured using a chemiluminescent enzyme immunometric assay. The predictive values of serum βhCG for establishing multiple pregnancy and pregnancy wastages were calculated by receiver operating characteristic (ROC) curve analysis. Median values of serum βhCG and outcome of all pregnancies were compared. Out of the 168 patients who conceived after IVF treatment, 114 (68%) were viable pregnancies (delivered/ongoing). Among the viable pregnancies, 97 (85%) had a successful pregnancy outcome and the remaining 17 patients are ongoing pregnancies. Median values of βhCG (625 IU/L) among viable pregnancies was significantly (P < 0.05) higher than that of nonviable pregnancies (174 IU/L). The median values of βhCG for singleton (502 IU/L), twins (1093 IU/L), and trip...Continue Reading

References

Oct 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D FeldbergJ A Goldman
Jan 1, 1995·Journal of Assisted Reproduction and Genetics·B GuthW L Gentry
Apr 17, 1998·Archives of Gynecology and Obstetrics·E Aboud, C Chaliha
May 1, 2001·Archives of Gynecology and Obstetrics·F ZayedH Alchalabi
Jul 3, 2002·Human Reproduction·P PoikkeusAila Tiitinen
Mar 24, 2004·Journal of Assisted Reproduction and Genetics·Francisco CarmonaJuan A Vanrell
Apr 20, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Thushari Indika AlahakoonPeter Illingworth
Oct 11, 2005·Fertility and Sterility·Hiroyuki FujiwaraMitsuaki Suzuki
Jul 4, 2009·Reproductive Biomedicine Online·Travis W McCoyHenry Cl Bohler
Jul 2, 2011·Fertility and Sterility·Caroline C LawlerRobert S Schenken

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Citations

Sep 6, 2014·Journal of Human Reproductive Sciences·Mariano MascarenhasTk Aleyamma
Oct 23, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lu HuangYanmin Ma
Aug 4, 2016·Journal of Obstetrics and Gynaecology of India·Neha Palo ChandelSidharth S Chandel
Feb 18, 2014·American Journal of Obstetrics and Gynecology·Maartje N NiemeijerRebecca C Painter

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Methods Mentioned

BETA
pregnancy test

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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