Role of Ectonucleotidases in Synapse Formation During Brain Development: Physiological and Pathological Implications

Current Neuropharmacology
Ivana GrkovićNataša Mitrović

Abstract

Extracellular adenine nucleotides and nucleosides, such as ATP and adenosine, are among the most recently identified and least investigated diffusible signaling factors that contribute to the structural and functional remodeling of the brain, both during embryonic and postnatal development. Their levels in the extracellular milieu are tightly controlled by various ectonucleotidases: ecto-nucleotide pyrophosphatase/phosphodiesterases (E-NPP), alkaline phosphatases (AP), ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) and ecto-5'- nucleotidase (eN). Studies related to the expression patterns of ectonucleotidases and their known features during brain development are reviewed, highlighting involvement of these enzymes in synapse formation and maturation in physiological as well as in pathological states. During brain development and in adulthood all ectonucleotidases have diverse expression pattern, cell specific localization and function. NPPs are expressed at early embryonic days, but the expression of NPP3 is reduced and restricted to ependymal area in adult brain. NTPDase2 is dominant ectonucleotidase existing in the progenitor cells as well as main astrocytic NTPDase in the adult brain, while NTPDase3 is fully ex...Continue Reading

References

Jul 15, 1992·The Biochemical Journal·H Zimmermann
Sep 1, 1991·Neurobiology of Aging·J L Fuchs
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Yoshioka, O Tanaka
Nov 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S NarisawaJ L Millán
Jun 17, 1998·Brain Research·T F Wang, G Guidotti
May 23, 1998·Advances in Experimental Medicine and Biology·T Page, M Coleman
May 20, 1999·Journal of Neuropathology and Experimental Neurology·A A LieS W Schoen
Sep 3, 1999·Mechanisms of Development·D BächnerG Gross
Oct 3, 1999·Neuroscience Letters·U BrändleJ P Ruppersberg
Jul 13, 2000·Brain Research. Molecular Brain Research·Y YamamotoH Yamashita
Dec 20, 2000·American Journal of Medical Genetics·A M PersicoF Keller
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M R SchetingerD Balz
Apr 23, 2003·European Journal of Pharmacology·P Nickolas ShepelJonathan D Geiger
Apr 26, 2003·The European Journal of Neuroscience·Norbert BraunHerbert Zimmermann
Aug 2, 2003·Neurochemistry International·Márcia R WinkAna M O Battastini
Nov 6, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alessandra Nejar BrunoJoão José Freitas Sarkis
Nov 20, 2003·Nature Neuroscience·Marcy A KingsburyJerold Chun
Dec 9, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Iraci Lucena S TorresMaria Beatriz C Ferreira
Mar 31, 2004·Seminars in Neonatology : SN·David Millar, Barbara Schmidt
Jun 15, 2004·Nature Medicine·Makoto InoueHiroshi Ueda
Jul 14, 2004·Critical Reviews in Neurobiology·Stephen P Hack, Macdonald J Christie
Sep 14, 2004·Mental Retardation and Developmental Disabilities Research Reviews·Beth A Malow
Oct 7, 2004·Neuropharmacology·Eric J Nestler
Oct 16, 2004·Molecular and Cellular Neurosciences·Michael A FoxBabette Fuss
Feb 26, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alessandra Nejar BrunoJoão José Freitas Sarkis
Feb 26, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N NedeljkovicG Nikezic
Jun 2, 2005·Cellular and Molecular Life Sciences : CMLS·F Ille, L Sommer

❮ Previous
Next ❯

Citations

Mar 1, 2020·International Journal of Molecular Sciences·Rosa MancinelliStefania Fulle
Dec 20, 2020·Biochemical Pharmacology·Gennady G Yegutkin
Jun 26, 2021·Neurochemistry International·Roberta AndrejewAna Maria Oliveira Battastini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.