Role of EFNB1 and EFNB2 in Mouse Collagen-Induced Arthritis and Human Rheumatoid Arthritis

Arthritis & Rheumatology
Yan HuHongyu Luo

Abstract

EFNB1 and EFNB2 are ligands for Eph receptor tyrosine kinases. This study was undertaken to investigate how the expression of Efnb1 and Efnb2 on murine T cells influences the pathogenesis of collagen-induced arthritis (CIA) and to assess correlations between the T cell expression of these 2 molecules and measures of disease activity in patients with rheumatoid arthritis (RA). CIA was studied in mice with T cell-specific deletion (double gene knockout [dKO]) of both Efnb1 and Efnb2. Expression of EFNB1 and EFNB2 messenger RNA (mRNA) in peripheral blood T cells from patients with RA was determined by quantitative reverse transcription- polymerase chain reaction. In dKO mice, clinical scores of arthritis were reduced compared to those in wild-type (WT) control mice. Serum collagen-specific antibody titers in dKO mice were lower than those in WT mice. In analyses based on equal cell numbers, dKO mouse T cells, as compared to WT mouse T cells, provided vastly inferior help to B cells in the production of collagen-specific antibodies in vitro. T cells from dKO mice were compromised in their ability to migrate to the arthritic paws in vivo and in their ability to undergo chemotaxis toward CXCL12 in vitro. Deletion mutation of Efnb1 an...Continue Reading

References

Apr 7, 1998·Clinical and Experimental Immunology·L SvenssonL Jansson
Apr 8, 1998·Annual Review of Neuroscience·J G Flanagan, P Vanderhaeghen
Nov 12, 1998·Arthritis and Rheumatism·F ImamuraK Nishioka
Jan 28, 1999·The Journal of Biological Chemistry·D LinT Pawson
Mar 24, 2000·International Review of Cytology·D G Wilkinson
Sep 15, 2001·Nature·C A Cowan, M Henkemeyer
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 17, 2002·The Journal of Biological Chemistry·Elisabeth Trivier, Trivadi S Ganesan
Oct 24, 2002·The Journal of Clinical Investigation·Hongyu LuoJiangping Wu
Feb 8, 2003·The EMBO Journal·Masamitsu TanakaHaruhiko Sugimura
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guang YuJiangping Wu
Sep 19, 2003·The Journal of Biological Chemistry·Guang YuJiangping Wu
Feb 28, 2004·The EMBO Journal·Masamitsu TanakaHaruhiko Sugimura
Oct 27, 2004·The Journal of Biological Chemistry·Guang YuJiangping Wu
Dec 16, 2004·The Journal of Clinical Investigation·Hongyu LuoJiangping Wu
Jun 2, 2005·Current Opinion in Hematology·Jiangping Wu, Hongyu Luo
Aug 8, 2006·Cell Metabolism·Chen ZhaoKoichi Matsuo
Jun 19, 2007·Trends in Cardiovascular Medicine·Sanne KuijperRalf H Adams
Aug 2, 2007·Kidney International·T HashimotoH Kawachi
Sep 26, 2007·Annals of the New York Academy of Sciences·Rossana ScrivoGuido Valesini
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yong-Sik BongIra O Daar
Feb 19, 2008·Genes & Development·Dina Arvanitis, Alice Davy
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Feb 18, 2009·The Journal of Experimental Medicine·Michelle A LintermanCarola G Vinuesa
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun ZhangHongyu Luo
Nov 2, 2011·Seminars in Cell & Developmental Biology·Ira O Daar
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Mar 7, 2012·The Journal of Biological Chemistry·Zenghui WuJiangping Wu
Mar 22, 2012·Autoimmunity·Eliana Mariño, Shane T Grey
Jun 15, 2013·Nature Reviews. Immunology·Anne DurandyAlain Fischer

❮ Previous
Next ❯

Citations

Apr 18, 2019·Investigative Ophthalmology & Visual Science·Yan HuJohn Danias
Nov 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aránzazu MedieroBruce N Cronstein
Apr 24, 2020·The Journal of Biological Chemistry·Wei ShiJiangping Wu
Apr 19, 2018·Frontiers in Endocrinology·Juan José MuñozAgustín Zapata
Jul 25, 2019·Frontiers in Immunology·Thayer K Darling, Tracey J Lamb
Jun 6, 2018·Frontiers in Immunology·Sara Montero-HerradónAgustín G Zapata
Oct 8, 2020·Cells·Javier García-CecaAgustín G Zapata
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Agnieszka Arthur, Stan Gronthos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.