Role of electrolyte abnormalities and unmeasured anions in the metabolic acid-base abnormalities in dogs with parvoviral enteritis

Journal of Veterinary Internal Medicine
Richard K BurchellA L Leisewitz

Abstract

The strong ion model (SIM) is an alternative paradigm in the characterization of acid-base disturbances particularly in complex disorders. To compare the acid-base changes in dogs with parvoviral enteritis (PE) using the Henderson-Hasselbalch (HH) approach, with 2 strong ion approaches. Forty-four dogs with PE, and 16 age-matched control dogs. Prospective controlled observational study. Acid-base status was evaluated using the HH model, Fencl-Stewart (FS) approach and a validated strong ion model (VDM). The acid-base changes according to each model were classified and compared. Statistical correlations between pH, CO2 , and various SIM variables were performed, as well as between the sum of effects (SOE) of the SIM and the individual variables comprising the SOE. The HH model identified acid-base disorders in 31/44 cases of which 16/31 were mixed with metabolic acidosis and concurrent respiratory alkalosis the most common (10/31). Using the FS approach, metabolic changes were present 36/42 cases, with changes in free water (FW), chloride, and unmeasured anions (UA) being the most prevalent. Both FW and UA correlated well with pH; however, UA were most consistently abnormal in severe acidemia. Similarly to the HH, the VDM detect...Continue Reading

References

May 12, 1976·Pflügers Archiv : European journal of physiology·D S EmuakporA N Zimmerman
Jan 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·O Siggaard-Andersen
Mar 27, 1982·British Medical Journal·C K BiswasD N Kerr
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J W Severinghaus
Jan 1, 1993·Respiration Physiology·V Fencl, D E Leith
Jan 23, 1999·Annals of Neurology·M S van der KnaapR A Chalmers
Nov 26, 1999·The Veterinary Clinics of North America. Food Animal Practice·P D Constable
Aug 31, 2000·Critical Care Medicine·T J MorganZ H Endre
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·V FenclJ Figge
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSEN
Sep 1, 1965·Anesthesiology·J P BUNKER
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Lewis J Kaplan, Spiros Frangos
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Ira KurtzMinhtri K Nguyen
Apr 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Miriam A M MoviatJohannes G van der Hoeven
Apr 25, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Marie-Odile Benoit, Jean-Louis Paul
Oct 12, 2010·The Veterinary Clinics of North America. Small Animal Practice·Amelia Goddard, Andrew L Leisewitz
Feb 1, 2011·The American Journal of Emergency Medicine·Jihad MallatLaurent Tronchon
Jan 10, 2012·Journal of the American Society of Nephrology : JASN·Robert G Luke, John H Galla
Jul 20, 2012·Journal of Veterinary Emergency and Critical Care·Pamela K FettigKristi M Gannon
Jul 19, 2013·Wiener klinische Wochenschrift·Nikolaus KneidingerValentin Fuhrmann
Aug 6, 2013·Journal of Critical Care·Miriam MoviatPeter Pickkers
Mar 13, 2014·The Veterinary Journal·Richard K BurchellAndrew L Leisewitz
Jul 19, 2014·Critical Care : the Official Journal of the Critical Care Forum·Fernando G ZampieriFabiano Pinheiro da Silva
Sep 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammed Al-Jaghbeer, John A Kellum
Sep 28, 2014·Respiratory Care·Jonathan Marhong, Eddy Fan
Dec 19, 2014·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miloš N Novović, Jasna Jevdjićt
Nov 26, 2015·Clinical Journal of the American Society of Nephrology : CJASN·L Lee HammKathleen S Hering-Smith
Jul 20, 2016·Journal of Intensive Care·Yoshifumi Kotake
Apr 19, 2017·Journal of Veterinary Emergency and Critical Care·Ivana Vanova-UhrikovaJaroslav Doubek

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Hepatology
Bernhard ScheinerGeorg-Christian Funk
Liver International : Official Journal of the International Association for the Study of the Liver
Georg-Christian FunkBruno Schneeweiss
© 2021 Meta ULC. All rights reserved