Role of ELISA D-dimer test in patients with unstable angina pectoris presenting at the emergency department with a normal electrocardiogram

American Journal of Hematology
David ShitritDan Zviony

Abstract

Patients with unstable angina pectoris and acute myocardial infarction have higher than normal D-dimer levels. The aim of the study was to determine the value of the D-dimer test in patients with unstable angina pectoris and a normal electrocardiogram on presentation at the emergency department. The study sample included 81 patients who met these criteria. Blood samples collected at admission were subjected to ELISA D-dimer. Findings were correlated with coronary risk factors, use of cardiac medications, blood levels of acute phase reactants (fibrinogen and C-reactive protein), cardiac enzymes levels, length of hospital stay, and catheterization findings. ELISA D-dimer levels were statistically significantly correlated with cardiac risk factors, namely male sex, older age, smoking, and hypertension (r = 0.25, P = 0.02; r = 0.43, P = 0.0001; r = 0.26, P = 0.03; r = 0.35, P = 0.002, respectively), in addition to use of cardiac medications (beta blockers, aspirin, nitrates), levels of acute phase reactants, length of stay, and catheterization findings. On multivariate analysis, only D-dimer level, age, and sex were predictors of length of stay (P = 0.018). The study suggests that D-dimer levels at admission to the emergency depart...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Mar 15, 1991·Journal of the American College of Cardiology·D AlexopoulosE A Fisher
Nov 26, 1987·The New England Journal of Medicine·J B KruskalR E Kirsch
Aug 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·D R EllisR F Ebert
Jun 1, 1996·Thrombosis Research·M VeitlT Vukovich
Jan 29, 1999·Lancet·A PerrierH Bounameaux
May 20, 1999·Circulation·A J MossR B Case
Aug 31, 2000·American Heart Journal·A Bayes-GenisA B De Luna
Jun 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J OldgrenL Wallentin

❮ Previous
Next ❯

Citations

May 31, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kai ZacharowskiPeter Petzelbauer
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Armaghan Y SoomroGeorge D Dangas
Nov 14, 2014·Clinical Medicine Insights. Cardiology·Kathrin HahneFrank Breuckmann
Dec 28, 2017·International Heart Journal·Zanxin WangMinxin Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.