Role of endogenous adenosine in atrial fibrillation after coronary artery bypass graft

Clinical Cardiology
Turhan YavuzAli Kutsal

Abstract

Atrial fibrillation (AF) is the most common complication following coronary artery bypass graft (CABG). The mechanism of AF after CABG is not well defined; however, it is suggested that endogenous adenosine, released in response to tissue hypoxia, may play a mechanistic role in these arrhythmias. The purpose of this study was to examine whether intravenous theophylline, via adenosine A1 receptor antagonism, would correct or modify new-onset early (<48 h post CABG) atrial fibrillation in patients post CABG, and thereby implicate endogenous adenosine as an inciting agent. A prospective double-blind, placebo-controlled study design was applied to 385 consecutive patients with coronary artery disease who had undergone CABG. Any patient who developed AF within 48 h of the operative procedure was randomly assigned to receive 5 mg/kg of intravenous theophylline (Group A) or matched intravenous placebo (Group B). The patients who converted to sinus rhythm within 15 min of drug administration were accepted as showing positive responses. Thirty patients comprised the study group. In Group A, 8 of the 15 patients (53%) converted from AF to sinus rhythm within 15 min of theophylline administration. One patient who converted to sinus rhythm...Continue Reading

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Citations

Mar 30, 2010·General Thoracic and Cardiovascular Surgery·Kiyoshi TamuraNaoto Miyagi
Jun 15, 2013·Pharmacology & Therapeutics·John P HeadrickJason N Peart
Sep 4, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Majid HaghjooMohammad Ali Sadr-Ameli
Nov 26, 2010·Biochimica Et Biophysica Acta·John P HeadrickLuke J Haseler
Jun 1, 2018·Physiological Reviews·Pier Andrea BoreaKatia Varani
Jul 10, 2019·Current Topics in Medicinal Chemistry·Jindian LiKai Chen

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